Where Does Oxalate Go?

Are the kidneys the primary pathway by which oxalate is removed from the body?

Yes, the kidneys are the primary pathway for oxalate removal from the body. The glomeruli filter oxalate and either excrete it directly in urine or secrete it by renal tubule cells. Around 90–95% of oxalate elimination occurs through the kidneys, while a small percentage is degraded by gut microbes or excreted via feces. If kidney function is impaired or overwhelmed, oxalate can accumulate in tissues, leading to conditions like oxalate nephropathy or systemic oxalosis. Maintaining proper hydration, electrolyte balance, and gut health supports oxalate clearance.

If kidney function is impaired or overwhelmed, where would oxalate accumulate?

If kidney function is impaired or overwhelmed, oxalate can accumulate in soft tissues throughout the body. Common sites include the renal parenchyma, bones, vascular walls, myocardium, retina, skin, and joints. In advanced cases, it may deposit in the thyroid, liver, lungs, spleen, and central nervous system. This widespread deposition—called systemic oxalosis—can cause inflammation, fibrosis, and organ dysfunction. The tissue preference often depends on local calcium concentrations and tissue perfusion, as oxalate forms poorly soluble calcium oxalate crystals, which trigger damage where they lodge.

Emunctories-What Are They?

Reading Time: 6 Minutes – Rebecca (Asmar) Krisko, ND – Content Source

Discussion: NotebookLM

Emunctories? What in the world…

How do you define an emunctory and the emunctories system?

An emunctory, most simply, is a “route of elimination.” But, a more complex understanding would be any process or location by which the body rids itself of toxic substances or waste products it does not need. Primary emuntories (GI, lung, skin, kidney) are the most efficient routes of elimination, when those are not working properly, the body will attempt to use secondary emunctories. These secondary emunctories are not only not as efficient, they are not “meant for” this job of elimination.

Therefore, secondary emunctories often develop an “itis” when the primary emunctories are not working. Any chronic “itis” is an indication of poor elimination through primary emunctories.

What are the physiological and philosophical differences between emunction and detoxification?

Philosophically: Emunction is proper physiology working well to process, filter, and eliminate toxins and waste products. Detox is an external force imposed on the body to drive out impurities.

Emunction is a passive process of optimizing function, detox is an active process of pushing out perceived contamination.

Physiologically: Emunction involves optimizing functionality of all major routes of elimination as well as considering what is required to properly process any ingested substances and to move the waste products through the fluid systems of the body to the proper routes. Detox, physiologically, involves stimulating the liver, removing external toxic exposures, and some kind of external process to eliminate (colonic, enema, sauna etc.)

Which of the emunctories is the most critical for care?

All are the most critical. All must be working efficiently to support optimal health.

What are the clinical applications of the emunctories systems? What are these clinical applications based upon?

Not sure what you mean by “based on,” but we apply the idea of opening emunctories as a first step in the treatment of every patient that comes to the clinic. We believe that most patients’ symptoms are at least partially the result of poor emunctory function, but also that open emunctories provide a stable foundation upon which to build optimal health. Open emunctories virtually guarantee fewer side effects or adverse effects of medications (both ND and MD remedies). In addition, once the emunctories are open and properly functioning, we can dive deeper into the physiology that will reveal the underlying reason why the patient became ill. Without this foundation of open emunctories, we would be dealing with many more complications as treatment progresses.

“The exultation of the vital force is accomplished by the stimulation of the emunctories.” Faber’s medical dictionary of 1865. Please elaborate.

When you provide gentle stimulus to the emunctories and watch them open and begin to function properly, you do, then, get to see the vital force in action. The body restores itself to proper function on many deeper levels just by returning these systems to balance.

What is the impetus for creating this elective?

If you know how to properly restore emunctory function, you know how to begin EVERY naturopathic case. Every patient will benefit from this foundational approach and it provides a very stable place for each naturopath to then use his/her own individual style to treat the case. Proper function on this level is the foundation for good ND care regardless of what else you choose to do. And our collective results will improve by many times if we all employ this approach in our practices before we do any type of external intervention.

Which classical methods do you employ to assess that a patient may need emunction/detoxification?

Asking basic questions about digestion, sleep, energy, appetite, mood, menses.
Assessing the case history by keeping emunctory function in mind. Like I said, all chronic inflammations are related to emunctory function. Must draw relationships between the chronic constipation of a patient and their skin rash that will not go away. But, it is easy to assess which patients need this when we believe that every patient needs this. Its not always that every patients emunctories are not functioning properly (although it is often the case), but every treatment plan requires proper emunctory support to be even more effective and to achieve long-lasting cure.

Would pulse taking, tongue reading and iridology be adequate complementary assessment tools for assessing emunctory function?

Yes, I believe these tools can add information to a case that is already developing. If you have good support in the case history, the family history and lab reports, these assessment modalities can add further pieces of the puzzle. When assessing emunctories in the context of a case, we are trying to put a puzzle together to determine the underlying cause of the patient’s imbalance. These tools can be invaluable at providing missing pieces.

Which common classical patterns require emunction?

Constipation, skin problems, joint problems, chronic inflammations “itises,” chronic discharges (cough, acne, etc…), congestion of any part of the body (edema, liver congestion like dysmenorrhea), weight issues esp. overweight patients, absence of proper immune function (never gets sick, autoimmune), any disease of growth/storage (cancer, cysts, growths, fibroids, high cholesterol), the list goes on & on…

What treatment modalities do you use to stimulate emunctories?

100 conscious breaths/day, water, get outside daily, castor oil packs, daily movement/exercise, dry skin brushing, acidophilus, 2 tbsp ground seeds daily, UNDAs, flower essences, acupuncture, gemmotherapies, homeopathy.

Where does emunction fit in your therapeutic order?

We do nothing before we are sure that the emunctories are functioning properly. If we treat before the emunctories are optimal, we risk the patient suffering unnecessary effects of treatment.

How do mental/emotional aspects of clearing emunctories manifest?

The emotional sphere can be included as a higher order emunctory. Our emotions are definitely one way in which we eliminate some of what we encounter on a daily basis. So, then, emotional symptoms can also be a product of opening the emunctories. As you decongest the GI in working with a constipated patient, anxiety might manifest indicating that the kidney is really the emunctory that needs your support in this process. So, emotions can also help to point the physician to the proper emunctory to support (lung-grief, kidney-anxiety/fear, liver-anger)

How is sound spiritual health associated with healthy emunctories?

We do not believe that sound spiritual health is possible without healthy emunctories. This is the place we are all trying to achieve… balanced physical and spiritual health… cannot have it without optimizing the basic fundamental processes of the body like elimination of wastes.

How do we communicate with other allied health practitioners what we are doing when we “open the emunctories?”

I think we just tell them we are optimizing the body’s ability to eliminate waste products. If properly managed, the function of the emunctories should not decline with age. Please elaborate on this statement.

I do not agree with this statement. I think that the natural decline of the emunctories IS the normal aging process and that “dying of old age” means partly that your emunctory function cannot keep up with the demand. More cells die than can be regenerated…

How could chronic back pain or a diagnosis of schizophrenia be managed through opening the emunctories?

Back pain is very common. If emunctories are not efficient, then waste products build up.

Where are they going to go??

An intelligent system will not deposit these waste products in the heart or brain(crucial organs). So often, they are deposited in the joint spaces. Chronic back pain goes away regularly by maximizing emunctory function.

Schizophrenia is a much more severe diagnosis. If the toxic products/wastes have crossed the BBB, then all systems are likely involved in this long term degeneration of health. Meaning that emunctories need to be opened first, then all the systems of the body will need to be supported and rebalanced to achieve any real progress on this diagnosis.

What are the emunctories of our living environment/earth and how do they correlate to our physiological emunctories?

Seems our living earth has obscured its emunctories, but we do have living systems for dealing with wastes/toxic byproducts. Respiration is one of these systems. Not only humans breath. Plants breathe also, but in reverse. So, our waste product CO2 is their fuel and their waste product O2 is our fuel. The oceanic soup has many mechanisms for processing byproducts of organic life and recycling them back into the environment as usable materials. And weather patterns are also an environmental balancing act. Our thunderstorm is the counterpart to an environmental event on the other side of the globe.

What is the role of public health and policy in keeping our environment clean and our emunctories properly open?

It is our responsibility to maintain our own personal health as a reflection of the overall health of the planet and I think it is our responsibility to maintain the health of the planet as a reflection of our personal health. Health has inherent value. We do not need to “prove” its benefit. By optimizing the wellness of our individual bodies and of the world, we provide an atmosphere in which spiritual growth and evolution can occur.


More Reading: https://pmc.ncbi.nlm.nih.gov/articles/PMC7217398/

Introduction-

The concept of the emunctories, the organs of elimination, has been a component of traditional medicine since the Greco-Roman Period. The concept has been incorporated into traditional medicine practices throughout our recorded history, up to and including modern naturopathic medicine. The conception of Emmuctorology is much more recent and took place at the First International Editorial Skamania Retreat of the Foundations of Naturopathic Medicine Project in 2007. Specifically, it arose in a breakout group of educators discussing the limitations of teaching the classical body systems relied on by conventional medicine. There was a general consensus that multi-system synthesis, such as psycho-neuro-immunology, was more representative of the naturopathic approach to the human body and made it easier to both teach and learn. During this discussion, Emunctorology was born, a multi-organ synthesis of the naturopathic approach to elimination synthesized with modern clinical and basic science. At the end of the discussion, the idea ignited in the larger plenary group when the break-out group reported. Within weeks a sponsor provided an untethered academic grant to develop an educational program which has now been taught in a number of North American Universities. It is obviously an idea whose time has come.

Definition-

Emunctorology is a synthesis of traditional naturopathic medicine practice and modern science that provides a multisystem construct allowing the integrated study of the organs of elimination (the emunctories), their functional relationships, the role they play in maintaining normal physiology (homeostasis) through the elimination of waste material and toxic substances, the pathophysiology that occurs if the emunctories function sub-optimally or are diseased, and the clinical strategies that are used in modern naturopathic medicine to treat, nourish, tonify, stimulate and sedate the emunctories in the maintenance of good health.

Creating a Synthesis-

The term emunctories come from the Latin root, ēmungere, for wiping or cleansing, and describes an organ or duct that removes or carries waste from the body. The etymological evolution into modern Italian, emungere, the verb ‘to drain’ is more indicative of the term’s modern use. The etymological relationship between the origins of the term mucous and emunctories finds a relationship to its use in modern naturopathic medicine. Emunctories describes organ or ducts with the physiological function that involves draining or removing waste materials from the body.

An important traditional concept in naturopathic medicine is that illness may result from the accumulation of potentially noxious waste products. Lindlahr noted that “Kuhne, the German pioneer of Nature Cure, claimed that ‘disease is a unit’ that it consists in the accumulation of waste and morbid matter in the system.” Restated in modern scientific idiom, Kuhne postulated that underlying all disease is the accumulation of both toxins and abnormal organic material (which would include cells and cellular components). The corollary of this postulate which forms the basis of nature cure is that the elimination of toxins and abnormal organic material is an important part of the healing process. The Reverend Dr. Bronby noted in 1882 that these wastes, which include imbibed toxins, endogenous toxins and exhausted blood corpuscles, are dealt with by the emunctories on a constant, involuntary basis. The emunctories function to eliminate both the waste produced by the thirty thousand billion body cells and the exogenous toxins absorbed from the environment either deliberately or involuntarily. Dr Guenoit considered the emunctories as important to the condition of health as food and digestion.

Emunctorology explores the complex processes by which the body rids itself of toxic substances or waste products and how the emunctories function to eliminate that which does not benefit the organism as a whole. Traditionally, the emunctories were divided into primary and secondary roles. The primary emunctories, classically, the bowel, kidney, lungs and skin, are the most efficient routes of elimination. When these are not functioning optimally, the body will attempt to compensate and use the secondary emunctories, including the stomach, liver, pancreas, spleen, lymphatic system, prostate and mucosal surfaces. These secondary emunctories are not as efficient at elimination as this is not the primary function of these organs or tissues. Consequently, when the primary emunctories are not functioning optimally, the secondary emunctories may also become perturbed and respond with a generalized inflammation. A chronic systemic inflammation therefore suggests to the naturopathic physician poor elimination through primary emunctories. This inflammatory state can present as a generalized fever with or without an inflammatory condition affecting specific emunctories such as bronchitis, colitis, vaginitis, sinusitis, eczema or gastritis.

The basic functions of those excretory organs herein termed emunctories have been understood for some time. The overall role of the GI tract, the kidney, the lungs and the skin in elimination and excretion of both exogenous and endogenous toxins is well known. What is not very well understood is the interplay between these different organ systems and the early indicators of dysfunction or sub-optimal organ function. The functional disturbance of the emunctories has been a core component of naturopathic practice theory. In contrast, it is not a core concept within conventional medicine and there is surprisingly little known about the etiology and early natural history of deficits in these organ systems. It is the naturopathic view that normal homeostatic (perhaps better termed homeodynamic) mechanisms are singularly dependent upon the proper functioning of all the emunctories (the organs of elimination), and that a dysfunction in one will affect the function of another and, moreover, may result in a cascade of deficits and dysfunctions, including fatigue, leaky gut syndrome, vasculitis, chronic infections, pruritis, joint pains, migraines among others. The end-result may be systemic inflammatory responses and potential multiple systems dysfunctions. Lindlahr considered the accumulation of poisons (toxins) and morbid matter (abnormal organic materials) to be amongst the primary causes of disease and that their elimination was essential for health.

The Future-

The emunctories are a complex and highly integrated physiological system, upon whose structural and functional integrity our health is vitally dependent. It is hoped that Emunctorology, the integration of the traditional thinking about the emunctories synthesized with modern scientific understanding, research and discoveries can provide a tangible benefit to educators and students; and through our future clinicians to our patients and the global community.

Oxalate Dumping

What is oxalate dumping?

Oxalate dumping refers to the process by which the body begins to eliminate accumulated oxalate—usually calcium oxalate crystals—stored in tissues, after a significant reduction in dietary oxalate. This release can overwhelm the body’s excretion systems and may lead to temporary symptoms such as joint pain, fatigue, rashes, urinary discomfort, cloudy urine, or changes in bowel movements. The phenomenon is not well-documented in mainstream medicine but is widely discussed in patient communities and among some functional and integrative health practitioners. It’s thought to occur in cycles and may last weeks to months.

My thoughts on dumping…

I have been studying human anatomy(form) & physiology(function) for the last 8 years. My reason for studying this has been to better understand why we, as humans, have been failing so miserably at achieving our fullest aging potential of 120+ years. I’m in school right now at ASU pursuing my degree in applied nutrition and health. The end goal is to be a registered dietitian in the state of California.

Something, and I don’t remember what, possessed me to read the book Toxic Superfoods this last December. To my shock and chagrin, I found my answer to many little things that had been an ugly part of my plant-based/whole-food diet trend over the last four years leading up to 2025. Oxalate was the missing puzzle piece that I had been looking for. Not only in my life, but seemingly as an answer as to why humans struggle to make it much past 75 years of life with little quality of life or years left.

My experience with oxalate dumping has manifested itself in my skin and I also imagine throughout many soft tissues throughout my body that I cannot directly observe from the outside. And so I use my skin as a gauge for a tool to measure my overall dumping process and progress.

In the months leading up to my first reading of Toxic Superfoods in December(24) I had inadvertently been reducing my oxalate intake by shifting my dietary focus to something much more animal-based. After reading Toxic Superfoods I pretty much adjusted my dietary intake of oxalate to somewhere between 150-200mg/wk. It has remained there for the duration. And I just finished reading the book for the second time now this last week.

I exercise quite a bit, and I also spend 20 minutes in a hot tub every day, 20 minutes in a steam room, and 20 minutes in a dry sauna, sweating and I get to watch the oxalate leave my body. See the attached picture. It pools in the front of my shorts while I sit in the steam room. I pour water over my shaved head and face too cool off and it collects. My suspicion is that this is the calcium that was likely bound up in my dermis/epidermis with the oxalate. That it comes to the surface and ultimately is then shed in the process of sweating.

Clearly, not putting dietary oxalate in my mouth or the common precursors that result in endogenous production of oxalate have helped my recovery quite a bit. But it is the exercise and the time I spend in the hot tub, steam room, and sauna that are really helping me out ALOT. My skin is looking younger at a rather rapid pace. It literally has a gloss to it that it has never had before and I am about to turn 53.

And so yes. I would like to be someone that could help others realize the role that oxalate is playing regarding our health and its potential to negatively affect our aging progress keeping us from reaching well beyond 100 years of age with a healthy body not hindered by the negative influence oxalate has in displacing calcium, magnesium, iron, and all of the other minerals in our body from reaching the places that our body needs them to be.

P.S. Just had another thought on how to see the difference between dietary oxalate and endogenously produced oxalate. Dietary oxalate likely keeps the minerals in our diet from making its way into our system by binding it up in our digestive tract where we simply end up passing it out through our colon where oxalobacter encounters it and breaks it down. And the endogenously produced oxalate is likely the one that binds to those minerals that actually do make their way into our circulatory system beyond our intestinal lumen, further complicating and hindering the process of getting our minerals to where the body needs them. Our soft tissues end up stocking up these displaced minerals, which end up in diagnoses like cutaneous calcinosis, myositis ossificans, and kidney stones.

Those are my thoughts. Hope they help…8)

How a High-Oxalate Diet Changes Gut Bacteria and Affects the Body

How a High-Oxalate Diet Changes Gut Bacteria and Affects the Body

Recent research shows that eating a lot of oxalates—compounds found in foods like spinach, beets, and almonds—can change the types of bacteria in your gut. These changes can affect important body processes like how we handle inflammation, cholesterol, blood pressure, and even how we clear waste like oxalates from our system.

Two gut bacteria are especially affected: Ruminococcaceae_UCG-014 and Parasutterella. Normally, Ruminococcaceae_UCG-014 helps prevent oxalate buildup, while Parasutterella can contribute to problems if it grows too much. A high-oxalate diet lowers Ruminococcaceae_UCG-014 and increases Parasutterella.

This imbalance can lead to hyperoxaluria, a condition where too much oxalate builds up in the urine, which can cause kidney stones and other health problems. But the good news is that a fecal matter transplant (FMT)—a procedure that replaces bad gut bacteria with good ones—can reverse this. Interestingly, the FMT doesn’t work by increasing bacteria that break down oxalates. Instead, it strengthens the gut lining and improves transport proteins in the gut that help remove oxalate from the body.

What Else Changes?

In just 15 days of eating a high-oxalate diet, mice showed signs of leaky gut and metabolic problems. Their intestines became inflamed and damaged. They also had less of a substance called 2-hydroxycinnamic acid, which helps the body make salicylates—natural anti-inflammatory compounds. This could explain why some people develop salicylate sensitivity while eating a high-oxalate or carnivore diet.

People on a carnivore diet should note that hydroxyproline (a protein building block found in collagen-rich animal foods) also increased oxalate levels in this study. That might explain ongoing oxalate issues some carnivores face.

Sulfur and L-Cysteine Handling

Parasutterella loves to consume L-cysteine, a sulfur-containing amino acid. L-cysteine is essential for managing blood sugar, reducing inflammation, and making glutathione, the body’s main detox chemical. If Parasutterella grows too much, it might lower L-cysteine levels, which could contribute to diabetes, weight gain, and even sulfur sensitivities. However, some balance is needed because L-cysteine can also help prevent calcium oxalate buildup.

Oxalate Transport and Blood Pressure

The gut uses special transport proteins (called SLC transporters) to get rid of oxalate. After FMT, more oxalate left through the feces instead of urine, showing that transporter activity had improved. Parasutterella makes a compound called succinate, which can affect how these transporters work. Succinate helps balance oxalate and citrate, a chemical that helps prevent kidney stones. Too much succinate, however, may increase blood pressure by interfering with how transporters work.

Cholesterol and Bile Acids

Parasutterella also influences cholesterol and bile acid levels. Some studies show it helps lower LDL (bad) cholesterol, especially when people eat resistant starches like cooked and cooled potatoes. It also helps regulate bile acids, which are needed to digest fats and remove cholesterol from the body. Parasutterella seems to reduce harmful bile acids while encouraging the body to make more of the helpful ones. This balance helps the liver stay healthy and may reduce the risk of fatty liver disease or liver damage.

Aromatic Amino Acids

Parasutterella also plays a role in handling aromatic amino acids like tyrosine and tryptophan. These amino acids are important for making brain chemicals like dopamine and serotonin. In the study, more Parasutterella was linked to less of a harmful byproduct called p-cresol, and more of helpful compounds like N-hydroxy-L-tyrosine (a dopamine precursor) and ethylphenol (which may fight fungal infections).

The Bottom Line

This study shows that eating a lot of oxalates changes the gut in major ways—lowering good bacteria like Ruminococcaceae_UCG-014 and increasing bacteria like Parasutterella. These shifts affect much more than oxalate levels. They influence inflammation, gut health, blood pressure, cholesterol, and even mental well-being. A low-oxalate diet might help restore balance, especially in people struggling with oxalate-related health problems.


https://pmc.ncbi.nlm.nih.gov/articles/PMC11776474/
https://pmc.ncbi.nlm.nih.gov/articles/PMC9037427/
https://pmc.ncbi.nlm.nih.gov/articles/PMC6776049/

Aging…Why Are We Failing?

Aging. Why are we failing so miserably to achieve our full potential of 122+ years? Why is it that we are currently, as a species, only achieving around 75 years? Let that sink in. This is a universal problem. Yes, there are some exceptions to this average. Outliers that only make it into their forties and some that make it into their nineties and a few that will join the club of centenarians.

There will always be the problem of genetics that will prevent a small number of newborns to lack certain physical traits that prevent them from living a full, unhindered lifespan and that is unfortunate. But for the rest that are born with all of their functionality intact and working properly, they are still, on average, failing miserably to achieve our full potential.

Over the last 8 years, I have spent much time, reading, researching, contemplating, and experimenting with all manner of different life practices to improve my own individual odds to appreciate a status that places me on the upper end of the outlier scale landing me somewhere above one-hundred years of age before I begin the next step of whatever it is that we call the afterlife.

Sleep, hydration, nutriment, and movement, in my opinion, appear to be at the top of the list of things that we have control over that can tip the scales in our favor. Direct environment is another key driver that will also determine the outcome of our existence. Our direct environment, which the outside of our body comes into contact with throughout our entire existence, covers a whopping 1,200 square feet. However, we only ever see about 22 square feet of it while the majority, the other 1,178 square feet starts at our lips and ends at our anus.

That means that what we call our skin, the part we can easily touch, on what most people refer to as the outside of their body, only makes up about 1.67% of our body’s total surface area. The rest of the body is not directly exposed to the outside world, aside from the sinuses and the lungs. The actual entrance into our body lies within the small intestine, where the food we put in our mouth passes through the tight junctions of the epithelial lining of our small intestine, which enters our portal vein, headed for its first stop, the liver, for further processing.

What are the environmental factors that negatively impact our bodies, hindering our ability to reach our full potential?

Time is our most valuable asset. It is our bank account that we spend from to purchase the things we need or want. We can do that in a number of ways, however, the most common these days is to simply work for others in what we call a job where we exchange our time for fiat currency to trade with others for the time(work) we don’t want to do, like hunting or farming for our daily bread, the clothes we wear, and the place we lay our head.

At this juncture, you are probably wondering when I will get to what I believe is the hurdle that is keeping us from achieving more than merely aging more gracefully. I want to age better, and I’m sure I’m not the only one. Being a universal problem that, for the most part, we are all, as a species experiencing, it would be nice if there were only one thing that could be adjusted to fix the problem. That is likely not the case, however, it is not outside of the realm of possibility. And even if there are many factors that lead to a diminished outcome, there will be one factor that shows up to the proverbial party more than any others. And that is the factor that I have been looking for. The factor that we can knock out first. Then we can continue working our way down the list solving for all of the other factors that will eventually leave us with the ability to make it to an unhindered 122+ years.

To be continued…

Soft Tissue Calcifications

Oxalic acid has a very strong affinity for calcium, forming calcium oxalate—a salt that is highly insoluble in water. The solubility product constant (Ksp) for calcium oxalate monohydrate is around 2.3 × 10⁻⁹, indicating that even small amounts of oxalic acid and calcium ions in solution will readily precipitate out as crystals. This high affinity is a major reason calcium oxalate is the most common component of kidney stones and why oxalate tends to deposit in tissues when calcium is present and oxalate clearance is impaired.

Calcium is normally present in several tissues, primarily where it plays structural or regulatory roles. About 99% of the body’s calcium is stored in bones and teeth, providing strength and rigidity. The remaining 1% is found in soft tissues and body fluids, where it supports critical functions. Normal soft tissue reservoirs include:

-Blood plasma and interstitial fluid (as ionized calcium and bound forms)
-Muscle tissue (especially within the sarcoplasmic reticulum, regulating contraction)
-Nerve tissue (for neurotransmitter release)
-Endocrine tissues (e.g., parathyroid glands for calcium sensing)
-Mitochondria (in many cells, where calcium regulates metabolism)

Calcium is essential, but its accumulation outside controlled compartments (e.g., as crystals in soft tissues) is abnormal.

There are dozens of distinct disorders—genetic, metabolic, infectious, autoimmune, and toxic—that can lead to soft tissue calcification throughout the body. These fall broadly into two categories: dystrophic calcification (where calcium deposits in damaged tissues despite normal blood calcium levels) and metastatic calcification (from elevated calcium/phosphate levels). Examples include:

-Chronic kidney disease
-Hyperparathyroidism
-Sarcoidosis
-Systemic sclerosis
-Dermatomyositis
-Tumoral calcinosis
-Idiopathic basal ganglia calcification
-Calciphylaxis
-Vitamin D toxicity
-Mitochondrial disorders
-Genetic phosphate metabolism disorders (e.g., ENPP1, ABCC6 mutations)

The actual number of recognized conditions likely exceeds 50, with overlapping mechanisms involving phosphate dysregulation, tissue damage, or crystal deposition.

Soft tissue calcification can result from a wide array of disorders, encompassing genetic, metabolic, autoimmune, infectious, neoplastic, and iatrogenic causes. These conditions can affect various body regions, including muscles, skin, joints, internal organs, glands, and brain tissues. Below is an extensive list of over 50 disorders and conditions associated with soft tissue calcification:​

1. Genetic and Hereditary Disorders

-Pseudoxanthoma Elasticum (PXE)
-Generalized Arterial Calcification of Infancy (GACI)
-Arterial Calcification due to Deficiency of CD73 (ACDC)
-Fibrodysplasia Ossificans Progressiva (FOP)
-Osteogenesis Imperfecta
-Ehlers-Danlos Syndrome
-Marfan Syndrome
-Loeys-Dietz Syndrome
-Alkaptonuria
-Mucopolysaccharidoses (e.g., Hurler, Hunter syndromes)
-Primary Familial Brain Calcification (Fahr’s Disease)
-Idiopathic Basal Ganglia Calcification
-Congenital Contractural Arachnodactyly (Beals Syndrome)
-Stickler Syndrome
-Hypermobility Spectrum Disorders

2. Metabolic and Endocrine Disorders

-Chronic Kidney Disease (CKD)
-Secondary Hyperparathyroidism
-Primary Hyperparathyroidism
-Vitamin D Toxicity
-Milk-Alkali Syndrome
-Tumoral Calcinosis
-Hyperphosphatemia
-Hypophosphatasia
-Diabetes Mellitus (leading to Mönckeberg’s Arteriosclerosis)
-Wilson’s Disease

3. Autoimmune and Connective Tissue Diseases

-Systemic Sclerosis (Scleroderma)
-Dermatomyositis
-Polymyositis
-Systemic Lupus Erythematosus (SLE)
-Mixed Connective Tissue Disease (MCTD)
-Rheumatoid Arthritis
-Sjögren’s Syndrome
-CREST Syndrome (a subset of systemic sclerosis)

4. Infectious Diseases

-Cysticercosis
-Tuberculosis (leading to caseous necrosis and calcification)
-Congenital Toxoplasmosis
-Cytomegalovirus (CMV) Infection
-Rubella
-Schistosomiasis

5. Neoplastic Conditions

-Osteosarcoma (primary or metastatic)
-Synovial Osteochondromatosis
-Calcifying Epithelial Odontogenic Tumor
-Pilomatricoma
-Calcifying Fibrous Tumor

6. Vascular and Cardiovascular Disorders

-Atherosclerosis
-Monckeberg’s Arteriosclerosis
-Calciphylaxis
-Chronic Venous Insufficiency
-Phleboliths (calcified venous thrombi)

7. Neurological Disorders

-Primary Familial Brain Calcification (Fahr’s Disease)
-Idiopathic Basal Ganglia Calcification
-Neurocysticercosis​

8. Trauma and Iatrogenic Causes

-Myositis Ossificans (post-traumatic)
-Heterotopic Ossification (post-surgical or post-injury)
-Injection Granulomas
-Iatrogenic Calcinosis Cutis (e.g., from calcium-containing IV infusions)

9. Idiopathic and Miscellaneous Conditions

-Idiopathic Scrotal Calcinosis
-Subepidermal Calcified Nodule
-Osteoma Cutis
-Calcific Tendinitis
-Diffuse Idiopathic Skeletal Hyperostosis (DISH)
-Calcinosis Cutis (various subtypes)

This compilation underscores the diverse etiologies and systemic nature of soft tissue calcification.

Oxalate Impact Summary

Oxalate Summary:
– Oxalates are compounds that come from oxalic acid and exist as acids or crystals, either soluble or insoluble.
– Oxalates can bind to positively charged elements like calcium, magnesium, and iron, forming crystals.
– Ingesting excessive oxalates can lead to kidney stones and crystal deposits in various body tissues.
– Oxalates are found in certain foods, including dark leafy greens (spinach, chard, beet greens), nuts (almonds, cashews, peanuts), non-gluten grains (buckwheat, quinoa), beans (black beans, white beans), sweet potatoes, chocolate, raspberries, kiwi, star fruit, and more.
– Oxalates are associated with inflammation, oxidative stress, and chronic health issues.
– Consuming large amounts of vitamin C, including through IV supplementation, can lead to oxalate crystal deposits.
– Avoiding high-oxalate foods can help reduce the risk of health problems associated with oxalate accumulation. Oxalates can cause fatigue and brain fog.
– High oxalate diet can damage gut and immune system.
– Reducing oxalates in food prep is food specific.
– Soaking nuts for 24 hours can reduce phytates but increase oxalic acid.
– Oxalate crystals irritate gut, don’t usually get absorbed into blood.

Low oxalate:
– Animal foods like meat and liver have low oxalate content.
– Low oxalate plant foods include lettuces, cabbage family vegetables, melons, cucumbers, winter squashes, white rice.

Symptoms:
– Oxalate-related symptoms: arthritis, headaches, skin issues, fungal infections, neural inflammation.
– Symptoms can arise during oxalate elimination as body clears stored crystals.
– Energy exhaustion during clearing is normal; healing can be a complex process.

Cycles of oxalate release can be observed and managed over time.

Oxalate poisoning can lead to various symptoms:
– Aches, joint pains, and muscle tension
– Migraines, headaches, and fibromyalgia-like pain
– Sleep disturbances and nighttime arousal
– Urinary tract and pelvic issues, including pain
– Blood cell problems, like low white blood cell counts
– Oxalates can contribute to fibrosis and scar tissue
– Oxalic acid interferes with cell functions and signaling
– Eliminating high oxalate foods can alleviate symptoms
– inclusion of some carbohydrates, such as sweet potatoes, can balance and temporarily reduce the rate of oxalate excretion.
– Different individuals respond differently to oxalates, so listen to your body

Kidney Stones & Estrogen:
– Estrogen is generally protective against kidney stones.
– Menopausal women are at higher risk of kidney stone formation when clearing oxalates.

Balancing pH and Citric Acid:
– Maintaining alkalinity in the body helps prevent kidney stone formation.
– Low citric acid levels in urine increase kidney stone risk.
– Alkalizing agents like lemon juice, potassium citrate, and mineral baths can help.

Research and Support:
– Medical research focuses on kidney stone prevention.
– Personalized approaches are necessary due to individual variations.
– Experiment with different mineral supplements and baths to find what works.

Healing and Mitochondria:
– Reducing oxalate consumption can support mitochondrial health.
– Adequate minerals, vitamins, and hydration are essential for cellular energy.
– B-vitamins and minerals like thiamine help improve mitochondrial function.

Mineral Bathing:
– Mineral baths, like epsom salts and sea salt, can aid in mineral replenishment.
– Potassium bicarbonate, baking soda, and boron may be beneficial.
– Gradually increasing bath frequency and duration can provide benefits.

– Mineral baths can be beneficial, especially for children who may not take supplements.
– Applying minerals through the skin can be effective for absorption.

Gut health:
– Claims of specific bacteria healing the gut and eliminating oxalate issues are often oversimplified.
– Gut health is complex, and restoring it to a perfect state is challenging due to the diversity of microorganisms needed.
– No single probiotic or bacteria can solve all gut-related problems.
– Historical evidence shows that oxalates from foods have caused health issues long before modern lifestyles.
– The kidney literature suggests that urine containing 25 milligrams or less of oxalate is considered normal.
– Our body produces about 12 milligrams of oxalate daily; dietary intake must stay within that limit.
– Good gut health allows absorption of 10-15% of dietary oxalates, making a daily intake of 150-200 milligrams reasonable.
– Leaky gut or certain health conditions may reduce tolerance to 50 milligrams of oxalate daily.
– Normal oxalate diet is 100-200 milligrams, while many popular foods exceed this limit.
– Adjust your oxalate intake based on gut health, avoid overconsumption, and consider consulting for personalized guidance.

LOTLR: The Why

As many of you are aware, I have been on a journey for some time now to better understand aging and how we can live a fuller life on our way to the final curtain call.

That road has had a lot of ups and downs, potholes and speedbumps, twists and turns, and a few hiccups along the way.

Clearly, there are a lot of factoral mechanisms at play in the equation of life, but alas, I believe that I ‘MAY’ have, and say this with great reservation for being wrong, found the x factor I have been looking for.

You see, mankind as a whole has been failing to make it much past eighty years of age with any consistency of practice. And yet we seemingly have the ability to make it to one hundred twenty years.

So why such an amazingly universal failure rate? Is it at all possible that there could be one universal unseen factor(x) in the equation of life that could be a prime mover or barrier preventing us from completing a fullness of years?

After many years of study, I’ve reached a point where I have found a factor(x). As I try to look around and see if there is something that fits in the equation, unlocking the door, if you will, I keep finding myself facing that same factor(x).

I am completely aware that I could be wrong, and I heartily welcome correction. However, this factor(x), as a key, is working in the door that has remained locked to me for a very long time. And I’ve spent many years looking for this answer.

As I’ve previously mentioned, several factors make up the equation of aging. I believe there are four main factors that we can adjust for that are under our control aside from genetics and geographic location: Optimal sleep, optimal hydration, optimal movement, and optimal nutrition. Each of these is dependent on the other to keep our machine(body) running efficiently. And I believe the x factor I keep mentioning is making one of these lifestyle factors run out of balance is affecting the overall performance of the human vehicle and our life’s journey to a long, healthy, and robust end well beyond one hundred years of healthy aging.

That x factor is oxalate, whether endogenously produced or exogenously procured in our diet. In my estimation, it is the gunk that is fouling our body, keeping it from appreciating a full life. It is slipping under the diagnostic radar like a thief in the night, robbing us of our most valuable asset: time.

I invite you to join me on this journey as I continue writing about it on my blog. I will also post it here on FB for you all to read, as I did this morning with Day 001 posted below.

I am sharing this with all of you freely because I want to see people be free of that which ails them. I would hate to think we all have a familiar(common) foe that manifests itself in many different ways, expressing itself in various places throughout the body because of our biochemical individuality.

I want to see all of us live a longer, healthier life. I don’t want to keep this to myself. I want you all to grow older with me but in a better place with a better body that makes life and our body a more enjoyable place to live. There is little worse than living out a miserably painful existence in a body that is fraught with various and myriad expressions of dis-ease.

Life on the LO(low oxalate) Road: Day 001

On September 26, 2018, Chew Digest was born. It was born out of a life of recovery that began on June 01, 2016. The first thing I removed from my life of toxicity was alcohol. Eventually, I removed caffeine and nicotine. And somewhere in between, in late 2017, I quit eating junk food, fast foods, and processed foods. I basically removed anything with a food label that had an ingredient list. Just good home-prepared/cooked foods using whole ingredients. The foundation for what I would later discover is called a whole-food diet.

That first iteration of a whole-food diet resulted in some pretty massive detox or die-off symptoms. What is called a Herxheimer reaction (Jarisch-Herxheimer reaction) is a temporary inflammatory response that occurs when the body rapidly kills off a large number of pathogens (bacteria, fungi, parasites, or other toxins), leading to a surge of endotoxins or cellular debris into the bloodstream. However, it can also occur during detoxification processes such as fasting, oxalate dumping, or significant dietary shifts (e.g., keto/carnivore adaptation).

It was one hell of a ride for a good six months before my body started finding balance again. A roller coaster of ups, downs, emotions, and extreme weight loss. I got down to 132.5lbs. It’s not a good look at almost six feet.

At that point, I understood very little about the inner workings of the human body, but I decided I wanted to better understand what had been happening and how I could prevent my life from ever finding itself back in that bad place that could have very well wrecked my life had I not made changes. So, I started reading and self-education, which has led me to where I am today.

What followed was a little over five years of many skin problems that, at some points, were rather scary. It’s not that my dietary changes triggered these problems, it is, as I understand it, what what allowed my body to continue purging from itself what had been going wrong under the hood(epidermis) for quite some time. My body had simply been walling off what it perceived to be a threat to its homeostasis. I would later come to understand that this is a common mechanism in our body’s bag of tricks to maintain homeostasis when it encounters something that it is having trouble processing out. It simply walls it off and forgets about it.

You may be wondering what those skin problems were. I certainly didn’t know what it was, and it wasn’t until a couple of years into my journey of recovery that someone put a name on it. A rather scary name, at which point I decided to involve a practitioner of Western medicine to get their input, and they confirmed what I had been made aware of just weeks earlier. He had a suggestion of how I should approach it according to the standard of practice. However, I had a different idea. I wanted to keep treating it as I had been on my own. Even now, I look back and think I was a little cavalier in my own handling of it, but I’ve come through it, and it is no longer a problem, and I did so without any external interventions.

To be continued…

Systemic Sub-Clinical Oxalosis

Systemic oxalosis occurs when oxalate accumulates beyond the kidneys, leading to widespread deposition of calcium oxalate crystals in soft tissues, bones, blood vessels, and organs. This condition is most severe in advanced kidney disease, where oxalate clearance is impaired.

Manifestations of Systemic Oxalosis

  • Renal: Worsening kidney failure, interstitial fibrosis, nephrocalcinosis
  • Cardiovascular: Vascular calcifications, hypertension, heart failure
  • Skeletal: Bone pain, fractures, osteomalacia due to oxalate deposits in bones
  • Dermatological: Skin ulcers, subcutaneous nodules
  • Neurological: Peripheral neuropathy, cognitive impairments
  • Gastrointestinal: Malabsorption, diarrhea, inflammation

Illnesses Resulting from Oxalosis

  • Chronic kidney disease (CKD) and eventual end-stage renal disease (ESRD)
  • Oxalate arthropathy (joint inflammation from crystal deposition)
  • Cardiac arrhythmias due to calcium dysregulation
  • Gastrointestinal disturbances and chronic inflammation
  • Systemic inflammation and oxidative stress-related diseases

Long-Term Effects of Sub-Clinical Oxalosis/Hyperoxaluria

  • Progressive Kidney Damage: Even without overt kidney stones, chronic hyperoxaluria can contribute to gradual renal decline.
  • Microvascular Damage: Persistent oxalate exposure may contribute to endothelial dysfunction, increasing cardiovascular risk.
  • Soft Tissue Ossification: Low-grade crystal deposition may drive dystrophic calcifications, similar to age-related atherosclerosis.
  • Chronic Inflammation & Oxidative Stress: Systemic low-level oxalate accumulation could contribute to conditions like neurodegeneration, metabolic dysfunction, and chronic fatigue.
  • Increased Risk of Osteopenia/Osteoporosis: Oxalate binding to calcium reduces bioavailability, potentially weakening bones over time.

Even at subclinical levels, persistent oxalate burden may accelerate aging processes and degenerative disease progression.