Drink Plenty of…

What is Earth’s most abundant solvent? Why, it is water, of course. It just happens to also be Earth’s most abundant corrosive agent.

Water is highly effective in promoting various types of corrosion and weathering processes due to its widespread presence and its chemical properties. Here’s why water is considered the most abundant corrosive agent:

1. Chemical Reactivity: Water can dissolve many substances, including salts and gases, which can lead to chemical reactions that cause corrosion. For example, when water dissolves oxygen, it can form oxidizing agents that contribute to rust formation in metals.

Electrochemical Corrosion: Electrochemical reactions can occur in the presence of water, leading to the corrosion of metals. Iron rusting is commonly seen, where water facilitates the transfer of electrons between iron and oxygen.

Physical Weathering: Water contributes to physical weathering through processes such as freeze-thaw cycles. When water enters cracks in rocks and freezes, it expands, causing the rocks to break apart.

Acid Rain: Water in the atmosphere can combine with pollutants like sulfur dioxide (SO₂) and nitrogen oxides (NOₓ) to form acid rain. Acid rain accelerates the corrosion of buildings, monuments, and other structures by reacting with materials like limestone, marble, and metals.

Hydrolysis: Water can participate in hydrolysis reactions, breaking down complex minerals and rocks into simpler forms. This process is a significant factor in the chemical weathering of rocks.

Biological Corrosion: Water supports the growth of microorganisms, which can produce corrosive byproducts. Certain bacteria, for instance, can produce sulfuric acid, contributing to the corrosion of concrete and metal structures.

Given its ubiquity and its involvement in various chemical, physical, and biological processes, water is undeniably Earth’s most abundant and effective corrosive agent.

Osmosis…Water ALWAYS follows salt

Maybe you are not dehydrated. Maybe you have an electrolyte deficiency disorder that is preventing you from achieving sufficient levels of hydration no matter how much water you drink.

What would an electrolyte deficiency disorder look like you ask?

Electrolyte deficiencies can present with a variety of clinical symptoms, depending on which electrolyte is deficient. Here are some common electrolyte deficiency disorders and their clinical presentations:

1. Hyponatremia (Low Sodium)
Symptoms: Nausea, headache, confusion, fatigue, muscle weakness, seizures, and in severe cases, coma.
Causes: Excessive water intake, heart failure, kidney disease, liver disease, and certain medications.

2. Hypernatremia (High Sodium)
Symptoms: Thirst, restlessness, irritability, muscle twitching, seizures, and coma.
Causes: Dehydration, excessive salt intake, diabetes insipidus, and certain medications.

3. Hypokalemia (Low Potassium)
Symptoms: Weakness, fatigue, muscle cramps, constipation, arrhythmias, and in severe cases, paralysis.
Causes: Diuretic use, vomiting, diarrhea, excessive sweating, and certain medications.

4. Hyperkalemia (High Potassium)
Symptoms: Muscle weakness, fatigue, numbness, tingling, arrhythmias, and in severe cases, cardiac arrest.
Causes: Kidney failure, excessive potassium intake, certain medications, and tissue damage.

5. Hypocalcemia (Low Calcium)
Symptoms: Numbness and tingling in fingers, muscle cramps, spasms, seizures, and cardiac arrhythmias.
Causes: Vitamin D deficiency, hypoparathyroidism, chronic kidney disease, and certain medications.

6. Hypercalcemia (High Calcium)
Symptoms: Nausea, vomiting, constipation, abdominal pain, muscle weakness, confusion, and in severe cases, cardiac arrest.
Causes: Hyperparathyroidism, cancer, excessive vitamin D intake, and certain medications.

7. Hypomagnesemia (Low Magnesium)
Symptoms: Muscle cramps, tremors, seizures, arrhythmias, and personality changes.
Causes: Alcoholism, malnutrition, chronic diarrhea, and certain medications.

8. Hypermagnesemia (High Magnesium)
Symptoms: Nausea, vomiting, muscle weakness, low blood pressure, respiratory depression, and cardiac arrest.
Causes: Kidney failure, excessive magnesium intake, and certain medications.

9. Hypophosphatemia (Low Phosphate)
Symptoms: Weakness, bone pain, confusion, respiratory failure, and in severe cases, seizures and coma.
Causes: Malnutrition, alcoholism, diabetic ketoacidosis, and certain medications.

10. Hyperphosphatemia (High Phosphate)
Symptoms: Itching, joint pain, muscle cramps, and in severe cases, calcium deposits in tissues.
Causes: Kidney failure, excessive phosphate intake, and certain medications.

Each of these electrolyte imbalances can have serious consequences if not addressed promptly. Diagnosis typically involves blood tests to measure electrolyte levels, and treatment depends on the underlying cause and severity of the deficiency or excess.

The Potassium Problem

Most people do not get enough potassium in their diets. It is estimated that LESS THAN 2% of Americans meet the recommended daily intake of 4,700 milligrams (mg) of potassium per day

Long-term subclinical hypokalemia, where potassium levels are slightly below the normal range but not low enough to cause obvious symptoms, can still have significant effects on the body. Here are some potential effects:

Cardiovascular System:

Arrhythmias: Even mild hypokalemia can increase the risk of cardiac arrhythmias, as potassium is crucial for normal heart function.

Hypertension: Low potassium levels can contribute to high blood pressure.

Heart Failure: Chronic hypokalemia may exacerbate or contribute to heart failure in susceptible individuals.
Muscular System:

Muscle Weakness and Cramps: While severe hypokalemia causes significant muscle weakness, even subclinical levels can lead to mild muscle weakness, cramps, and fatigue.

Rhabdomyolysis: In rare cases, prolonged mild hypokalemia can lead to muscle breakdown, known as rhabdomyolysis.
Renal System:

Kidney Function: Potassium is essential for kidney function, and long-term hypokalemia can impair the kidneys’ ability to concentrate urine, leading to polyuria (increased urination).

Nephropathy: Chronic hypokalemia can contribute to kidney damage and nephropathy over time.
Metabolic Effects:

Glucose Intolerance: Potassium plays a role in insulin secretion and function. Low potassium levels can lead to glucose intolerance and potentially increase the risk of diabetes.

Metabolic Alkalosis: Chronic hypokalemia can cause metabolic alkalosis, a condition where the body becomes too alkaline, leading to a variety of metabolic disturbances.

Neuromuscular Effects:

Fatigue: Persistent low potassium can lead to general fatigue and lethargy.
Neuropathy: Although less common, chronic hypokalemia may contribute to peripheral neuropathy.
Bone Health:

Osteoporosis: There is some evidence suggesting that chronic low potassium levels may contribute to bone demineralization and increase the risk of osteoporosis.
Gastrointestinal System:

Constipation: Potassium is important for normal muscle contractions, including those in the gastrointestinal tract. Low levels can lead to decreased motility and constipation.

Potassium helps the brain send signals to the digestive system’s smooth muscles, which then contract to move food and aid digestion. Potassium channels also play a role in slow-wave production, gastric contraction, and acid secretion.

Potassium channels play a prominent role in gastrointestinal smooth muscle cells and slow-wave production. Potassium channels are involved in acid secretion and gastric contraction. Gastric functional problems such as reflux disease and motility disorder are classified as electrophysiological disorders.

The shortfall in potassium intake is largely due to dietary patterns that are low in fruits and vegetables, which are the primary sources of potassium. Increasing the consumption of potassium-rich foods like bananas, oranges, potatoes, spinach, and beans can help address this deficiency.

Dearest People of Earth

People of Earth,

My name is Michael Loomis. I am a Southern California native. I have spent almost every day of my life in Long Beach, a Los Angeles suburb. I’ve spent 51 years here, and I love it. Everything about this place.

I wanted to take a moment and talk to ALL of you today. We are living in a fabulous time, a time when more people have access to basic goods and services necessary to make life possible without overdue burdens. By no means have we solved poverty and starvation on a global scale, but we are witnessing a revolution in technology, industry, and now intelligence that is allowing us to understand better how we can meet ALL of our basic needs. Food, shelter, clothing, and health care.

Over the last few decades, we have witnessed unprecedented growth in computer technology, which has allowed us to access vast amounts of data in a very short space of time. The libraries of the world are now online, which allows our large language models to be accessed by artificial intelligence engines in a way and at a rate that the human mind could have never imagined just a few short decades ago. In no uncertain terms, we are now witnessing the advent of a new age. An Intellectual Revolution born out of the foundation of the Industrial Revolution that began in the middle of the eighteenth century.

The time has come and now is when and where we need to embrace and welcome the reality of where we are in the passage of time. We have been born into a time and space where human labor and planning for the future are becoming a thing of the past—things that our future generations will only be able to understand through the lens of history. Whether it is our children, grandchildren, or great-grandchildren, there will come a day in the near future when that last job will no longer need to be filled. No more working by the sweat of our brow to provide for our daily bread. Our basic needs. And we need to prepare for it. There will be no more inequities.

And now I imagine you have a question that has been swirling around, forming in your mind about how we are going to prepare for this inevitability. This, I imagine, is followed by another question: What are we going to do with all the time that will be freed up because of this inevitability? And if there is no more work that needs to be done, how are we going to pay for our basic needs and luxuries?

At this point, we already live in a time of luxury compared to all of recorded human history. Consider that. Now consider this: We humans are the only species on Earth that has had the inclination to take that which was once free and accessible to all and put it behind lock and key. Food, shelter, and clothing were historically accessible to all mankind long before there were jobs, payroll, banks, and human resource departments. And today, if someone down on their luck is caught taking that which is behind lock and key without paying for it, we then put them behind lock and key, giving them food, shelter, and clothing, their basic needs for free. Kind of ironic, isn’t it?

Allow me to address some of those questions about the future that are likely swirling around in your head.

First of all, just because there will be no more jobs, that doesn’t mean that there will be no work to be done. Far from it. There will be plenty for us to do to ensure that all goes well. However, it will look different. The reality is that we are all going to need to accept these changes in work and meaning because the old way will have faded off into obscurity.

No longer will a household, say a family of four, need to work forty to eighty hours a week just to meet their basic needs. And I can hear the question now, “But who’s going to pay for it all?”

This is the wrong question to ask. The right question would be, “Why would we still need to pay for it?” The answer would be that we need to remedy the problems that led to the need to pay for it and replace them with solutions that would eliminate 84% of the financial burden that requires our human resources in exchange for pay.

trillion divided by million United States Citizens is approximately $70,262.

And then there is the money that employers add to the pot that would be freed up to fund the future.

The total cost to an employer for an employee extends well beyond the hourly wage due to benefits, insurance, office space, taxes, and other related expenses. This total cost is often referred to as the “burden rate” or “fully loaded cost.” The specific amount can vary significantly depending on the industry, location, and size of the company, as well as the specific benefits offered. Here’s a breakdown of some of the typical additional costs:

  1. Benefits: This can include health insurance, dental and vision insurance, retirement benefits (e.g., 401(k) contributions), life insurance, and disability insurance. Benefits can add 20% to 40% or more to the base salary.
  2. Employer Payroll Taxes: In the United States, for example, employers must pay Social Security and Medicare taxes, which amount to 7.65% of the salary. There might also be federal and state unemployment taxes.
  3. Workers’ Compensation Insurance: This varies by industry and state but is a mandatory cost for most employers.
  4. Training and Development: Costs associated with onboarding, training, and professional development can also add to the total cost.
  5. Office Space: The cost of providing a workspace, which includes rent, utilities, office supplies, and equipment, can vary widely depending on location and the nature of the business.
  6. Technology and Equipment: Computers, software licenses, communication tools, and other technology needs can add to the cost.
  7. Miscellaneous Costs: Other costs can include travel expenses, employee perks and wellness programs, and administrative support.

On average, the additional costs can range from 1.25 to 1.4 times the base salary, but this is highly variable. For a more precise calculation, it’s essential to consider the specific factors related to the industry, location, and company benefits package. Employers often conduct a detailed analysis or use calculators provided by HR services to estimate these costs accurately.


Policy basics: Where do our federal tax dollars go? (2023). Center on Budget and Policy Priorities. https://www.cbpp.org/research/policy-basics-where-do-our-federal-tax-dollars-go

More to come…Back to homework for now…8)

Colonization. A Virus of the Mind?

Is there any point in time where the species homo sapiens sapiens wasn’t engaging in the act of colonization? I think not. And it is my suggestion that it is an intrinsic part of human nature and existence. That at the very least there was at some point in human evolutionary development a beneficial and necessary use for it as a function. My question now, though, is, does it still serve that same purpose as beneficial for evolution, or is it a part of evolution that is truly fading away?

Personally, I would like to think that colonization is in a state of atrophy, ultimately becoming functionless in human evolution.

Why do we inherently, as humans, want to colonize everything? Because it is a virus we have. A virus of the mind.

Perhaps a poem?

From cradle, to grave, what first steps taken?
Amongst ancient echoes ancestors awaken.
From a primal urge, to an endless drive,
We seek, we explore, we expand, to thrive.

Down verdant valleys, over rugged peaks,
Our relentless quest, a conquering spirit seeks.
Is it a force of nature, primal, raw, unrefined?
Yes, colonization – a virus of the mind.

This tribal aspiration toward empire inclined,
These seeds of dominion, domination refined.
The human species conquered and mined,
Through every era this behavior entwined,

Our urge to conquer, to claim, to bind,
What distant treasures await we will find?
To what do we owe this quirky desire,
Will it grow like a flood, or burn out like a fire?

The world we know shrinks under our gaze,
This mystery of old continues to amaze.
We ponder most deeply, evolutions fair stride,
Is this urge now a relic to be cast aside?

Will these ancient impulses still find room,
What once was progress, now slated for doom.
In a world so connected, no longer so vast,
I sense a shift, a call to recast.

This virus of mind, once vital, now lame,
Humanity ponders evolution’s new aim.
This ancient desire, through atrophy fade,
Once evolution whispers, a new way is made.

We once were seekers of lands to possess,
Now stewards of self, undoing distress.
A mind’s fair dance through time and space,
Perhaps a new rhythm will find its place.

From conqueror to healer, transitions we make,
Survival in balance, for our planet’s sake.
As nomads of history, we write in our genes,
A bold new chapter of destiny convenes.

Preceding CO2 Transport: Respiration

January 7, 2024

Me: What process precedes carbon dioxide transport?

ChatGPT: The process that precedes carbon dioxide (CO2) transport in the body is cellular respiration. This is a metabolic process that occurs in the cells of organisms. Here’s a brief overview of the process: 

  1. Glycolysis: This is the first step of cellular respiration and takes place in the cytoplasm of cells. Glucose, a six-carbon sugar, is broken down into two three-carbon molecules called pyruvate. This process produces a small amount of ATP (adenosine triphosphate, the energy currency of the cell) and releases electrons that are used in later stages.
  2. Pyruvate Oxidation and the Citric Acid Cycle: Pyruvate enters the mitochondria of the cell, where it is converted into acetyl CoA, a two-carbon molecule. Acetyl CoA then enters the citric acid cycle (also known as the Krebs cycle), where it is completely oxidized to carbon dioxide. This process generates more electrons for the next stage and a small amount of ATP.
  3. Electron Transport Chain and Oxidative Phosphorylation: This is the final stage of cellular respiration and occurs in the inner mitochondrial membrane. The electrons generated in the previous steps are used to create a proton gradient across the membrane. This gradient drives the synthesis of a large amount of ATP. Oxygen serves as the final electron acceptor and combines with protons to form water.

After the production of CO2 in the citric acid cycle, CO2 is then transported out of the cell into the blood, where it is carried to the lungs for exhalation. The transport of CO2 involves several mechanisms, including being dissolved directly in the plasma, chemically bound to hemoglobin, or converted into bicarbonate ions.

Me: What are the steps that precede glycolysis in the answer you provided?

ChatGPT: Before glycolysis in the cellular respiration process, there are key preparatory steps involving the intake and processing of nutrients:

  1. Nutrient Intake: The first step involves the consumption and digestion of food. Carbohydrates in the food are broken down into simpler sugars like glucose, which is a primary fuel for glycolysis. Proteins are broken down into amino acids, and fats into fatty acids and glycerol. These components are absorbed into the bloodstream through the digestive system.
  2. Transportation to Cells: Once in the bloodstream, glucose and other nutrients are transported to various cells throughout the body.
  3. Glucose Uptake by Cells: Cells take in glucose from the bloodstream. This process is facilitated by insulin in many types of cells. Insulin is a hormone that signals cells to increase glucose uptake, effectively lowering blood sugar levels.
  4. Glucose Activation: Before glucose can enter the glycolysis pathway, it must be “activated”. This involves phosphorylation (adding a phosphate group), which is carried out by enzymes like hexokinase. This step uses energy in the form of ATP, converting it to ADP (adenosine diphosphate). The phosphorylation of glucose helps to keep the concentration of glucose low in the cell, allowing for continued glucose diffusion into the cell.

These steps ensure that glucose is available and prepared for the glycolysis pathway, which then leads into the rest of the cellular respiration process.

Me: Can you explain this whole process step by step from ingestion of nutrients to the end of the process where we exhale the CO2 from our lungs?

ChatGPT: Certainly! The journey from nutrient ingestion to the exhalation of carbon dioxide is a complex and fascinating process that involves multiple systems in the body. Here’s a step-by-step explanation:

 1. Ingestion and Digestion of Nutrients

  • Ingestion: It starts with eating food, which contains carbohydrates, proteins, and fats.
  • Digestion: In the digestive system, these nutrients are broken down:
    • Carbohydrates are broken down into simple sugars like glucose.
    • Proteins are broken down into amino acids.
    • Fats are broken down into fatty acids and glycerol.
  • These nutrients are then absorbed into the bloodstream, primarily in the small intestine.

2. Transportation and Uptake of Glucose

  • Transport to Cells: Glucose and other nutrients are transported via the bloodstream to various cells in the body.
  • Cellular Uptake of Glucose: Cells absorb glucose, facilitated by insulin, a hormone that regulates blood sugar levels.

3. Cellular Respiration: Energy Production from Nutrients

  • Glycolysis:
    • Occurs in the cytoplasm of cells.
    • Glucose is converted into pyruvate, producing a small amount of ATP (energy) and NADH (an electron carrier).
  • Pyruvate Oxidation and Citric Acid Cycle:
    • In the mitochondria, pyruvate is converted into Acetyl CoA.
    • Acetyl CoA enters the Citric Acid Cycle (or Krebs Cycle), producing more NADH, FADH2 (another electron carrier), and a small amount of ATP.
    • Carbon dioxide is released as a waste product in this cycle.

4. Electron Transport Chain and ATP Production

  • Electron Transport Chain:
    • Located in the inner mitochondrial membrane.
    • NADH and FADH2 from previous steps donate electrons, which are passed through a series of proteins in the membrane.
    • This process creates a proton gradient across the membrane.
  • Oxidative Phosphorylation:
    • Protons flow back across the membrane through an enzyme called ATP synthase.
    • This flow drives the production of a large amount of ATP.
  • Oxygen’s Role: Oxygen acts as the final electron acceptor, combining with protons to form water.

5. Carbon Dioxide Transport and Exhalation

  • Transport of CO2:
    • The carbon dioxide produced in the mitochondria diffuses into the bloodstream.
    • It’s carried in the blood in three forms: dissolved in plasma, chemically bound to hemoglobin, or as bicarbonate ions.
  • Return to the Lungs: Blood transports CO2 back to the lungs.
  • Exhalation: Finally, CO2 is expelled from the lungs when we exhale.

Integration of Systems

This entire process involves an intricate collaboration between the digestive, circulatory, respiratory, and endocrine systems, demonstrating the complex harmony of human physiology. From the initial ingestion of food to the final breath that expels carbon dioxide, each step is crucial for the efficient production and utilization of energy in the body.

Me: Yes, and thank you ChatGPT.

Are Humans Well Suited For a Frugivore Fare?

This is my response to a post in a friends Facebook group that promotes a more fruit based diet. Enjoy…

<–MY OPINION–>Personally, I still believe that we are omnivores best suited for a whole-food, single-ingredient diet. A diet made up of a whole collection of single ingredients rather than highly processed foods.

Can someone consume a frugivore fare and live healthy and well? I believe they can for a time. Perhaps maybe even for a long time. It really just depends on whether or not they can get a broad enough spectrum of ALL the nutrients and building blocks their body needs in their daily fare. Most cannot in our modern world, and eventually, the wheels will fall off of their under-nourished frugivore bus. Maybe not in 2 years, or 5 years, or even 10 years, but eventually, the nutritional piper will need to be paid.

On the other end of the spectrum(extreme), you have the cray cray carnivores. They can get along just fine for a time too. But eventually, in like manner, the wheels will fall off of their bus as well. For them, though, it will be a woefully painful calling of metabolic madness.

Both diets, in my opinion, are different wings of an omnivore bird.

And this is why I still believe that we are best served by being a well-balanced omnivore in the dietary portion of our existence.

Life is meant to be lived as a well-formed and balanced kingdom where exercise is King and diet is Queen, and without both, you don’t have a kingdom.

Work hard, eat right, and sleep right. If you can do these three things almost everything else will follow and fall into place according to natural law.

Listen to your body. Even if it is telling you something that may not concur with the path you have been on for some time.

Again, this is my opinion, based on my studies of human physiology and disease pathology over the last 6+ years. Thanks for reading…😎 and be blessed.

A New Model

Car mechanics wouldn’t try to learn how cars work by only studying individual components of a car or by looking at toy cars, but this is essentially how medical science has been taught over the years. They should be working with real humans, learning how existing, fully functioning, complex human creatures work. Not focusing so deeply on misfolded proteins or just one system and correcting that single system or misfold with a pill, but reshaping the whole misfolded protein(human) mess from the inside out.

I am Adam Matryoshka

The human species is not simply a bunch of rugged individuals all living on a blue marble orbiting the sun but a single entity. And for the fun of it, I will refer to this creature as ADAM and that ADAM lives amongst 8.7 million other species of plants and animals here on the third rock from the sun.

That we, as individual discrete organisms, are actually microorganisms within the greater macro-organism, ADAM. Which is also a species-level micro-organism consisting of some 3.8 million parts working together within Mother Nature, or what some might call Biofilm Earth.

Mother Nature(Earth) is a holobiont, and we(ADAM), too, are a holobiont. And who knows, maybe even our cells and microbes within us are also holobionts. Like a Matryoshka doll all the way down. Holobiont refers to an organism and its symbiotic partners (typically microbial) together as a single biological entity. The concept underscores the idea that the macro-organism and its microorganisms are so interconnected that they operate functionally as a single unit. The term “holobiont” derives from “holo-” (meaning whole or entire) and “biont” (meaning living entity). The combined term suggests an integrated system where the host organism and its associated microbial communities interact in ways that influence each other’s fitness, development, and evolution.

ADAM is simultaneously a discrete whole as well as a part of a larger whole. ADAM can be understood as the constituent part–wholes in and of a hierarchy. ADAM is a subsystem within a larger system, simultaneously evolving while also a part of a greater evolving system composed of other species as well.

ADAM is, by definition, a holon. Holons are self-reliant units with a degree of independence and can handle contingencies without asking higher authorities for instructions. Holons are simultaneously subject to control from one or more of these higher authorities. Holons are stable forms that can withstand disturbances and are intermediate, providing a context for the proper functionality of the larger whole.

I want to present a better, more accurate, simpler, more holistic understanding of how something like the black plague, Spanish flu, or our most recent species-level event that just happened is not spread by an invisible viral particle or a demon but through quorum sensing and mirror neurons. Basically, it is a communication system used by what I will refer to as bacteria(INDIVIDUAL HUMANS) to monitor and respond to changes in population density by altering gene expression. Essentially, it’s a way for bacteria(HUMANS) to “talk” to each other and coordinate their behavior, much like individuals in a large crowd of discrete species adjusting their actions based on the number of other species around them. This coordinated behavior allows human populations to act as multicellular entities in certain contexts.

That, what we are experiencing in these species-level pandemics is a coordinated event orchestrated by our species host, or ADAM and his immune system, to cleanse HIS body(the whole of humanity) of its diseased and dying cells(individuals) within the context of the holobiont(Adam), that is living as an individual species(holon) within a greater holobiont we call Mother Earth.

Protein Deamination is Our Damnation

Do you eat a protein-rich diet? Do you take any protein supplements because you are trying to build big muscles in the gym?

Have you ever met or known someone with a protein deficiency? Someone who truly had a protein deficiency? That’s because the only people who ever suffer from insufficient protein have to live in a part of the world where food is scarce or non-existent. In places like Sub-Saharan Africa, Southeast Asia, and Central America. It is usually prevalent in children and newborns. During times of hunger induced by natural calamities — such as droughts or floods — or political upheaval, these countries often have a limited supply or absence of food.

Lack of protein in the diet causes Kwashiorkor. Protein is found in every cell in your body. Protein is required in your diet for your body to repair and replace cells. This is how a healthy human body regenerates cells regularly. Protein is particularly necessary for growth in children and during pregnancy. When the body is deficient in protein, growth and regular bodily functions slow down, and kwashiorkor develops. (1) (Kwashiorkor, n.d.)

Today, in the United States we are living in what is called a postindustrial world/society. A postindustrial society is marked by a transition from a manufacturing-based economy to a service-based economy, a transition that is also connected with subsequent societal restructuring. Postindustrialization is the next evolutionary step from an industrialized society and is most evident in countries and regions that were among the first to experience the Industrial Revolution, such as the United States, western Europe, and Japan. (2) (Robinson, 2013)

To reiterate, in the United States, we live in a postindustrial world/society. And as such we have no want for even the most basic of nutritional needs. And the reality is that most of us in the United States have access to and consume too much good stuff, food, and otherwise.

As such, I will demonstrate below why our health is suffering so badly in this world of plenty we call home. The short answer is…Too much protein. When we consume protein above and beyond our body’s physiological needs, our body’s innate mechanisms become the machinery that forms the basis of our damnation. Our early demise.

The following is a simplified explanation of what happens inside the human body when we consume protein above its immediate needs at any moment in time.

Deamination is the process of removing an amino group from an amino acid. This process is crucial because it allows the amino acid to be converted into a form that can be used for energy production or other metabolic processes. It is

It’s important to note that while gluconeogenesis is a critical metabolic pathway, the body generally prefers to use carbohydrates and fats as the primary sources of energy, resorting to protein catabolism as a significant energy source only under conditions of dietary deficiency or metabolic stress.

When the body uses amino acids for energy, deamination occurs in the liver, converting the nitrogen-containing amino group into ammonia, which is then converted into urea and excreted by the kidneys. The remaining part of the amino acid, which is now without the amino group, enters various metabolic pathways, including the Krebs cycle, for energy production or the synthesis of glucose or fatty acids.

Which bodily process happens first, proteolysis or deamination?

The process by which the body breaks down protein into individual amino acids is called “proteolysis.” This process involves the breakdown of the peptide bonds that link amino acids together in proteins. Proteolysis is carried out by enzymes known as proteases and peptidases. It occurs in various parts of the body, including the stomach and small intestine, where dietary proteins are digested, as well as within cells, where proteins are continually broken down and recycled. Proteolysis is a key step in protein metabolism, allowing the body to utilize the amino acids for various functions, including new protein synthesis, energy production, and other metabolic processes.

Proteolysis occurs before deamination in the sequence of protein metabolism. Here’s the typical order:

  1. Proteolysis: This is the first step, where proteins are broken down into individual amino acids. Proteolysis happens through the action of digestive enzymes in the gastrointestinal tract for dietary proteins or by cellular enzymes for endogenous proteins.
  2. Deamination: Once amino acids are released from proteins, they are used for various purposes. Deamination may occur if an amino acid is to be used for energy or converted into other compounds. This is the process where the amino group is removed, typically in the liver.

Proteolysis is the initial process that releases amino acids from proteins, and deamination is a subsequent step that further modifies amino acids for various metabolic needs.

When proteins are metabolized, they are broken down into their constituent amino acids. A key component of these amino acids is nitrogen. During the catabolism (breakdown) of amino acids, the amino group (NH2) is removed in a process called deamination. This process occurs mainly in the liver.

Nitrogenous wastes are a byproduct of the metabolism of proteins and nucleic acids. The digestive process breaks down proteins into amino acids, which then enter the body’s metabolic pathways, producing nitrogenous wastes.

Removing the amino group results in the formation of ammonia (NH3), which is toxic. The liver then converts this ammonia into less toxic substances, mainly urea in mammals, including humans. This conversion is part of the urea cycle. The urea is then transported to the kidneys, where it is filtered out of the blood and excreted from the body in urine.

To reiterate, nitrogenous wastes, particularly ammonia and urea, which are byproducts of amino acid deamination, are harmful to the brain, soft tissues, and the cardiovascular system due to their toxic effects, especially in high concentrations. Here’s why:

  1. Ammonia Toxicity: Ammonia, a direct byproduct of deamination, is highly toxic, especially to the brain and nervous system. It disrupts normal cellular and neurological functions.
  2. Urea and Osmotic Imbalance: While urea, which is less toxic than ammonia, is a safer way for the body to transport and excrete nitrogen, high levels of urea cause osmotic imbalances. This leads to dehydration and stress on cells, including those in the cardiovascular system.
  3. Metabolic Acidosis: Accumulation of nitrogenous wastes leads to metabolic acidosis, a condition where the blood becomes too acidic. This impairs cardiovascular function and damages heart tissue.
  4. Inflammation and Oxidative Stress: Excess nitrogenous waste induces inflammation and oxidative stress, contributing to tissue damage and atherosclerosis (hardening of the arteries).

The body normally converts ammonia to urea in the liver (via the urea cycle) and excretes it through the kidneys to avoid these harmful effects. However, suppose this system is overwhelmed(over-consumption) or impaired (as in liver or kidney disease). In that case, nitrogenous waste levels become dangerously high, leading to toxicity and damage beyond the body’s ability to repair.

What kind of diets result in higher levels of nitrogenous waste?

Diets that result in higher levels of nitrogenous waste are typically those rich in proteins and nucleic acids. This is because the metabolism of these macronutrients involves the removal and excretion of nitrogen:

  1. High-Protein Foods: Foods with high protein content are the primary contributors to increased nitrogenous waste. This includes:
    • Meat (beef, pork, lamb, poultry)
    • Fish and seafood
    • Eggs
    • Dairy products (milk, cheese, yogurt)
    • Legumes (beans, lentils, soy products)
    • Nuts and seeds
  2. Foods Rich in Nucleic Acids: Nucleic acids (DNA and RNA) are also metabolized into nitrogenous wastes, though to a lesser extent than proteins. Foods that are particularly high in nucleic acids include:
    • Organ meats (liver, kidney, heart)
    • Seafood (especially sardines, mackerel, and shellfish)
    • Yeast and yeast extracts

To reiterate, when these foods are digested, the body breaks down their proteins into amino acids and their nucleic acids into nucleotides. The nitrogen-containing parts of these molecules are then converted primarily into urea, which is excreted by the kidneys.

When consuming a diet high in protein, it is important to support the kidneys in effectively processing and eliminating these nitrogenous wastes. Excessive protein intake over an extended period strains the kidneys, particularly in individuals with preexisting kidney conditions.

Here is what one should expect if one consumes a high-protein diet that results in excess proteolysis and deamination.

  1. Atherosclerosis: There is evidence that certain metabolic by-products of protein contribute to atherosclerosis and the buildup of plaques in the arteries.
  2. Calcifications, Vascular and Otherwise: In the context of kidney disease, conditions like hyperphosphatemia (high phosphate levels) occur due to excessive protein intake. This leads to vascular and other systemic calcifications and is a significant risk factor for cardiovascular disease.
  3. Hypertension: High protein intake, especially from animal sources, increases blood pressure, a major risk factor for CVD. This complex relationship involves various factors, including changes in kidney function and fluid balance due to the handling of the by-products of protein metabolism.
  4. Kidney Stress and Damage: The kidneys filter waste products, including those produced during deamination. Excessive deamination overburdens the kidneys, leading to or exacerbating kidney diseases, including chronic kidney disease and azotemia.
  5. Increased Urea and Uremia: As a result of excessive deamination, urea levels in the blood increase, leading to a condition called uremia, where the kidneys cannot filter it efficiently. Uremia has been associated with an increased risk of cardiovascular disease, as it contributes to factors like endothelial dysfunction, arterial stiffness, and inflammation.
  6. Inflammation: Chronic kidney disease and uremia lead to systemic inflammation, which is a known contributor to cardiovascular disease.
  7. Liver Disorders: Since the liver converts ammonia (a by-product of deamination) into urea, excessive deamination stresses the liver. In cases of liver dysfunction, ammonia may not be adequately converted, leading to hyperammonemia, which is toxic, especially to the brain.
  8. Metabolic Effects: Chronic consumption of excessive protein, especially animal protein, has various metabolic effects, such as increasing the risk of kidney stones, altering calcium balance, affecting bone health, and impacting kidney function, especially in individuals with pre-existing kidney disease.
  9. Metabolic Acidosis: Deamination leads to an accumulation of acidic compounds in the body. It disrupts the body’s acid-base balance, leading to metabolic acidosis. This condition causes fatigue, rapid breathing, confusion, and in severe cases, shock or death.
  10. Alterations in Gut Microbiota: High protein intake, particularly from animal sources, alters the composition and function of the gut microbiota. This has various implications for gut health and possibly systemic inflammation.
  11. Electrolyte Imbalances: The process of deamination and the subsequent handling of its by-products affects the balance of electrolytes in the body, potentially leading to imbalances that affect muscle and nerve function.
  12. Bone Health Issues: Excessive protein intake and deamination affect the body’s calcium balance, leading to bone loss and increased risk of osteoporosis.

At this point in time, I believe this is likely the most significant modifiable factor to our species overall mortality. Imagine if a pharmaceutical company offered a single pill that could prevent all of these 12 problems. Everyone would be clamoring for it, the individual that stumbled across this solution would be considered a savior of mankind.

There is a way to do this with a pill. If you still don’t see the solution, if it is not obvious, please don’t hesitate to ask me how.

  1. Kwashiorkor. (n.d.). S10.fit. https://www.s10.fit/blogs/disease/What-is-the-cause-for-Kwashiorkor/
  2. Robinson, R. C. (2013, November 19). Postindustrial society | Urbanization, Automation, Globalization. Encyclopedia Britannica. https://www.britannica.com/money/topic/postindustrial-society