Car mechanics wouldn’t try to learn how cars work by only studying individual components of a car or by looking at toy cars, but this is essentially how medical science has been taught over the years. They should be working with real humans, learning how existing, fully functioning, complex human creatures work. We should not focus so deeply on misfolded proteins or just one system and correct that single system or misfold with a pill; instead, we should reshape the whole misfolded protein(human) mess from the inside out.
Get in, start the car, take it for a spin, run it through its paces, and see if it functions as it is intended to. Don’t trust a mechanic that focuses too narrowly on the functionality of your lugnuts or the muffler bearings. Then, apply the same logic to your doctor if you need one.