senescence – Chew Digest

Anti-fragility and Hormesis

What Doesn’t Kill You Makes You What?

Is it possible that a random bacon double cheeseburger could ultimately make a vegan live a longer, healthier life? What if a raw vegan or even a frugivore could live ten to twenty years longer by simply eating something that is not within their strict framework every once in a while? Is it possible that consuming a diet that is too easy on the system is actually worse than one that is not?

I am beginning to wonder. Because complex organic operating systems are weakened, sometimes even unto an early demise where there is a lack of stress. And as we have seen over the last few years, 2019-2022, Mother Nature does not favor the weak. On the contrary, she favors the strong.

I can’t imagine each and everyone one of us hasn’t heard this many times over. Kelly Clarkson made a hit song with this title in 2011. It’s not just a catchy song, it is also a very true statement within a complex system that has the ability to adapt. In the scientific and medical worlds, it is referred to as anti-fragility or hormesis.

In Greek mythology, there was a story about a creature with nine heads called Hydra. The monster would occasionally emerge to stir up the people and livestock of the mythical land of Lerna. When someone attempted to defeat this creature by cutting off one of its heads they would find that two more grew back in its place. What didn’t kill Hydra made him stronger.

This concept can also be seen in the plant world through a process called topping in which the main stalk of the plant is cut resulting in the plant redirecting its energy and growth hormones out to the side branches resulting in the branches growing more robustly in an outward fashion instead of continuing skyward. The intended result is a plant that produces more fruit.

And this is why you see so many humans working out. What doesn’t kill us does quite literally make us stronger. You see, some things benefit from a shock to the system that pushes a smooth running organic machine out of balance. Even our bones grow stronger when put under stress by physical activity. But there does come a point where that stress can become too much and the benefits are no longer as robust. This brings me to my another question I will address later. How much is too much?

So, back to the double bacon cheeseburger question. Could an occasional curveball actually be better for the human body than a perfectly executed raw vegan diet? It would seem so. Even Dr. Valter Longo, author of The Longevity Diet notes that those who indulge in a small amount of fish once per week ultimately live longer healthy lives than those on a strict, 100% uncooked whole-food/plant-based diet. Nonetheless, he still stresses the importance of maintaining a 95% whole-food/plant-based diet. But I don’t really remember ever hearing him clearly state what that mechanism of action is by adding a little fish to the diet.

My feeling is that it boils down to the hormetic/anti-fragile effects of the animal food product acting as a small amount of poison that kicks our body’s immune system into high gear. That just a few ounces of fish once per week causes our body to produce an excess amount of neutrophils, eosinophils, basophils, monocytes, and lymphocytes that then go out into the body to fix the problem.

And this is where the magic happens.

Not only is the specific poison addressed by all of those amazing immune cells that our body produces for times just like these, but they also go about cleaning up a whole host of other lesser things that were flying just below the radar at a subclinical level improving the overall health of the human body. Cleaning up other senescent cells that are no longer beneficial to life, but not quite problematic enough to trigger an immune response. Individually, those senescent cells won’t take out the creature(us), but over time they will and do build up to a level that eventually precipitates a health crisis that most aren’t even aware of until we start experiencing systemic inflammation requiring an interventional response.

*Fruitarian vs. Centenarian

“Blessed are the flexible, for they shall not be broken.”

I’ve been studying human physiology and disease pathology for the last 4.5 years. A part of that study has been dedicated to observing the practices of the longest living people on Earth. Our centenarians. Groups of people that live in these specific five places called Blue Zones.

1. Okinawa, Japan
2. Sardinia, Italy
3. Nicoya, Costa Rica
4. Ikaria, Greece
5. Loma Linda, California.

There are a number of things that they have in common. One of them is a whole-food/plant-based diet. To be a little more specific, people in these so-called Blue Zones typically eat a 95% plant-based diet that’s rich in legumes, whole grains, vegetables, and nuts, all of which can help reduce the risk of death.

Strangely…None of these groups are fruitarians.

In late 2020, I was introduced to a practice called Natural Hygiene. The natural hygiene diet is a system of healthy living whereby moral, physical, and environmental pollution is strictly avoided, and natural, healthy food is chosen in preference over processed foods. The principle is to provide everything the body needs to be healthy and to avoid anything that may hinder health and well-being.

One of the hallmarks of this system, as it is practiced today, is a diet that primarily consists of juicy sweet fruit and gentle leafy greens. Small amounts of nuts and seeds are also on the approved list. This system also tends to focus on a practice called food combining and also the opposite which is mono-meals where only one kind of fruit is eaten until the consumer is full and then rotating through a variety of fruits and gentle leafy greens.

I have been practicing this way of eating for the past year myself and have found it to be very VERY beneficial in its ability to help the body heal and cleanse itself from the inside out. This will always be a part of my dietary practice.

But is eating this way what the human body needs to find its way to its fullest potential of living to 120 years and possibly well beyond to a place above 144 with a body that looks no more than today’s middle age?

I cannot say for sure, because there are no models that exist outside of religious texts that demonstrate this much less suggest this. And those practitioners that have been promoting this way of eating over the last 100-150 years have never themselves accomplished our fullest human longevity potential, much less in large communities. Or even small groups for that matter. Most haven’t even lived any longer than any average Joe that didn’t have any particular practice, but those in the Blue Zones have.

For me, I will continue on looking for better answers, and practicing what I preach. I will be continually pressing into the practices of what I can observe is working in the each and everyday practices of those that also practice what they preach. But I will not be so stubborn as to ignore the proofs that exist in our day in favor of rigid structures of beliefs in contrast to actual evidence of that which actually brings forth fruit.

I will continue to learn, grow and adapt. A wise man I knew once said, “Blessed are the flexible, for they shall not be broken.” Thanks for the wisdom Chuck(Smith).

Cancer, aging and cellular senescence.

Inducers of Senescence, Toxic Compounds, and Senolytics: The Multiple Faces of Nrf2-Activating Phytochemicals in Cancer Adjuvant Therapy

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Normal cells do not divide indefinitely due to a process termed cellular or replicative senescence. Several lines of evidence suggest that replicative senescence evolved to protect higher eukaryotes, particularly mammals, from developing cancer. Senescent cells differ from Continue reading Cancer, aging and cellular senescence.