Proteolysis and Aging. Why I Take Serrapeptase and Lumbrokinase(Sometimes)

What is the relationship between proteolysis and aging?

Note: The use of these enzymes should likely be for a limited time span only. I will use them for a two-week period once every few months to clean out the aging cobwebs…8). The reason why is explained in the last paragraph.


Proteolysis refers to the breakdown of proteins into their constituent amino acids or smaller peptides, typically by enzymatic action. In the context of aging, proteolysis is an essential part of cellular maintenance and repair mechanisms, which are critical for health and longevity. Here are some potential benefits of proteolysis on aging:

1. Clearance of damaged proteins: Over time, proteins can become damaged due to various factors like oxidative stress, exposure to harmful substances, etc. Damaged proteins can become dysfunctional and may contribute to age-related diseases. Proteolysis helps in clearing these damaged proteins, maintaining the health of cells and tissues.

2. Autophagy and longevity: Proteolysis is a key part of autophagy, a cellular process of self-digestion where damaged organelles, misfolded or aggregated proteins are degraded and recycled. Dysfunctional autophagy has been linked with aging and age-related diseases. Enhancing autophagy through proteolysis might promote longevity and slow down the aging process.

3. Regulation of protein homeostasis (proteostasis): Aging is associated with a decline in proteostasis, the balance of protein synthesis, folding, and degradation. Proteolysis is a major factor in maintaining proteostasis, which is crucial for cellular function and health.

4. Activation of beneficial pathways: Certain proteins, when broken down through proteolysis, can activate pathways that are beneficial for health and longevity. For example, proteolysis of certain proteins can activate mTOR (mechanistic target of rapamycin), a key regulator of aging.

5. Immune system function: Proteolysis can support immune system function, which often declines with age. The process helps present antigens to immune cells, aiding in the recognition and clearance of pathogens and potentially cancerous cells.

6. Cell signaling: Proteolysis also plays a role in various cell signaling pathways, many of which can impact aging. For example, Notch signaling, which is regulated in part by proteolysis, is involved in cell differentiation and tissue homeostasis.

While proteolysis appears to have beneficial effects on aging, it’s also important to note that uncontrolled proteolysis can lead to muscle wasting and other detrimental effects. Balance is key, and maintaining optimal levels of proteolysis is important for health and longevity. Further research is needed to better understand how to regulate proteolysis for anti-aging benefits.

-Michael J. Loomis & ChatGPT

Fasting, Longevity, and Workaholism.

Hi, my name is Michael and I’m a workaholic…LoL

I really do enjoy working 7 days a week, however, that can get exhausting; not just physically, but also emotionally. So I’ve been trying something a little different. Working 7 days a week, but then taking a 4-day break once a month. I may eventually try to focus my work attention a little more to get to the point where I can do that twice a month. Work 10 days on and then 4 days off.

This time around; on this 4-day break, I decided to fast. Just water for 72 hours. Woooooof. Knocked me the hell out. But now that I am 64 hours into it I am feeling much better and well cleansed. My skin looks wonderful and what little inflammation I had has reset back to what it should be.

I may even consider doing this once a month. Ironically if I did it would save me at least 10% on my monthly food bill. Not a bad savings in times like this. And as a benefit, it is well known in the scientific and medical community/literature that a 72-hour fast or prolonged fasting can lead to regeneration of the cells of your immune system. Imagine; resetting your immune system so that it can fight a better fight leading to better health and ultimately greater longevity.

I decided on 72 hours because I’ve gone much longer before. That and I had 4 days off to deal with the yucky feelings. My understanding is that those yucky feelings(keto flu) are a result of the body catabolizing its own, what we call stored fats. I imagine this is where the body stores a lot of the toxins that it can’t process now for processing later should we choose to do something beneficial like fasting. Which likely would have been a default thing that we have lost in time because of this world of plenty we have been enjoying for decades.

So I imagine the reason we begin feeling better after a few days is that our body has had a chance to clear out the toxins that were stored up for later processing which is accomplished through the act of fasting.

P.S. I’ve been doing a 12/12 feeding schedule for quite some time now. That seems to offer the best benefits overall. Metabolic and other health concerns arise when going above or below the 12-hour feeding window.

I know I’ve spoken to you guys a lot about eating certain ways and how important it is, but I really want you guys to know that longevity of years is and should be the ultimate goal. But even more with a body that looks and feels no more than 24.

We’ve been given by right of birth a gift of a potential 120 years of time that we are miserably failing to attain, and why anyone wouldn’t want to live to 120 years or more is beyond me. Especially if we could do it with a body that is functionally 24 years of age.

I do want to and plan to live to 120. I do realize that I am likely going to have to bury a lot of people I love that don’t want to live a lifestyle that lends towards that end, but I, at this point, cannot see it any other way. I want to fully appreciate the gift we have all been given. Why shouldn’t we?

I am going to try. Why not try it with me?

Anti-fragility and Hormesis

What Doesn’t Kill You Makes You What?

Is it possible that a random bacon double cheeseburger could ultimately make a vegan live a longer, healthier life? What if a raw vegan or even a frugivore could live ten to twenty years longer by simply eating something that is not within their strict framework every once in a while? Is it possible that consuming a diet that is too easy on the system is actually worse than one that is not?

I am beginning to wonder. Because complex organic operating systems are weakened, sometimes even unto an early demise where there is a lack of stress. And as we have seen over the last few years, 2019-2022, Mother Nature does not favor the weak. On the contrary, she favors the strong.

I can’t imagine each and everyone one of us hasn’t heard this many times over. Kelly Clarkson made a hit song with this title in 2011. It’s not just a catchy song, it is also a very true statement within a complex system that has the ability to adapt. In the scientific and medical worlds, it is referred to as anti-fragility or hormesis.

In Greek mythology, there was a story about a creature with nine heads called Hydra. The monster would occasionally emerge to stir up the people and livestock of the mythical land of Lerna. When someone attempted to defeat this creature by cutting off one of its heads they would find that two more grew back in its place. What didn’t kill Hydra made him stronger.

This concept can also be seen in the plant world through a process called topping in which the main stalk of the plant is cut resulting in the plant redirecting its energy and growth hormones out to the side branches resulting in the branches growing more robustly in an outward fashion instead of continuing skyward. The intended result is a plant that produces more fruit.

And this is why you see so many humans working out. What doesn’t kill us does quite literally make us stronger. You see, some things benefit from a shock to the system that pushes a smooth running organic machine out of balance. Even our bones grow stronger when put under stress by physical activity. But there does come a point where that stress can become too much and the benefits are no longer as robust. This brings me to my another question I will address later. How much is too much?

So, back to the double bacon cheeseburger question. Could an occasional curveball actually be better for the human body than a perfectly executed raw vegan diet? It would seem so. Even Dr. Valter Longo, author of The Longevity Diet notes that those who indulge in a small amount of fish once per week ultimately live longer healthy lives than those on a strict, 100% uncooked whole-food/plant-based diet. Nonetheless, he still stresses the importance of maintaining a 95% whole-food/plant-based diet. But I don’t really remember ever hearing him clearly state what that mechanism of action is by adding a little fish to the diet.

My feeling is that it boils down to the hormetic/anti-fragile effects of the animal food product acting as a small amount of poison that kicks our body’s immune system into high gear. That just a few ounces of fish once per week causes our body to produce an excess amount of neutrophils, eosinophils, basophils, monocytes, and lymphocytes that then go out into the body to fix the problem.

And this is where the magic happens.

Not only is the specific poison addressed by all of those amazing immune cells that our body produces for times just like these, but they also go about cleaning up a whole host of other lesser things that were flying just below the radar at a subclinical level improving the overall health of the human body. Cleaning up other senescent cells that are no longer beneficial to life, but not quite problematic enough to trigger an immune response. Individually, those senescent cells won’t take out the creature(us), but over time they will and do build up to a level that eventually precipitates a health crisis that most aren’t even aware of until we start experiencing systemic inflammation requiring an interventional response.

What’s Keeping Us From Living Our Fullest Life?

Look at the fangs on this fuzzy fella. He is a gibbon and gibbons are frugivores.

I used to think that the reason we humans have these teeth in our mouth that we call canines is that we were meant to eat meat. Well, this fuzzy fella has some crazy-looking fangs, yet he only eats fruit all day.

 

I’m not saying that we cannot eat meat, because surely we can and do. But just because we call 4 teeth in our mouth canine teeth and they vaguely look like what a canine has a mouthful of doesn’t mean that meats were to be eaten by us in the amounts we do.

I still plan on continuing my non-animal fare as long as wisdom leads me down that path. It makes the most sense to me from my studies over the last 4.5 years on how the human body works BEST.

Can we eat meat? Sure. Should we eat meat? Not to the extent that most of us do if there is plenty of fresh plant-based/whole-foods are readily available. But hey, if you happened to find yourself lost in the Arctic and subarctic regions of Greenland, Canada, and Alaska and the only things the Inuit have to offer is seal, then eat up my friend. It’s better than the other option.

If malnourishment were the other option for me I already have a plan in place for how I would go about consuming it. I’d rather be prepared than be caught off guard in that eventuality.

Can we humans fully function on a completely whole-food/plant-based diet alone? I am and I know a lot of other people that are doing it too, and we are all doing just fine. Am I 100% convinced that any one of us vegan, vegetarian, omnivore, or carnivore has it all figured out? No. There may yet be a better answer still.

These days we are living in a world of plenty where we have so many good options that we actually have the luxury to actually choose to do as we like. Something a lot of humans couldn’t have done just 150 short years ago. Many were just trying to maintain health or even simply survive. And sadly many suffered from all manner of malnourishment diseases that have been virtually vanquished in this world of plenty we live in today.

I personally can’t wait for the first person that has figured out how to live more than 120 years with a body that looks, feels, and functions like a healthy 24. It will start with a single person with sight beyond their own short life. A person that understands that there are things that are within our midst, within our grasp, within our power to control. Principles by which we can become the fullness of the life that was intended to be used by the intelligence that saw fit to gather our elements together into a cohesive bundle of energy. A life force bound up in this unique form for a purpose.

What Has Changed?

Since some of you asked, I thought I would answer like this.

What has your experience been since moving away from a raw vegan “fruitarian” lifestyle/diet?

Two BIG changes that I feel are a move in the right direction are…

  1. Better bowel movements
  2. No more trips mid-night trips to the bathroom

I really had no expectations that these two things would take place. But frankly, both are tremendously beneficial results in my book. My bowels appear to be much happier and I’m getting a better quality of sleep. There are a couple of reasons for this that I will explain below. My gut just feels more at peace. It’s kind of hard to explain.

What foods I have changed.

  1. Sweet Potatoes
  2. Vegetable Soup
  3. Daily Green Boost

What else I have changed.

I start my day with my largest caloric intake so that by the end of the day my body is better able to find rest before I go to sleep at night. I start heavier at breakfast(break fast) and then I go lighter as the day goes on. I am currently on a rotation where I have a large salad one day, a big bowl of vegetable soup the next day, and a big bowl of sweet potatoes on the third day. This makes the most amount of sense to me. It’s also easier.

On the days I eat my salads and soups, I supplement Daily Green Boost with bananas mashed up along with shelled hemp seeds and chia seeds. It’s like a deep dark green banana-flavored tapioca pudding. I know some will decry foul with my combining fruits with fats, but I would disagree on a physiological level. Our body in its infinite wisdom combines both lingual lipase and alpha-amylase in our salivary glands together precisely for the digestion of both starches and fats. And nature wouldn’t create a perfect fruit like an avocado which contains both fats and carbohydrates if they weren’t supposed to be consumed at the same time. But alas there will be some that suggest we shouldn’t be eating avocados. I disagree with them on this point as well. Just don’t eat too much avocado in one sitting. Go easy on this wonderful fruit.

On the days I eat sweet potatoes, I will have a large and hydrating banana and berry smoothie for lunch with coconut water and coconut milk combined with Daily Green Boost.

I still eat fruit throughout the day, but just not as much. I also have changed my eating window to something called Time-Restricted Feeding. Some of you may call it Intermittent Fasting, but I believe the former is a better way of understanding what it is that is happening physiologically. Because until someone stops putting calories into their body, they are not fasting. And I believe that even the use of the word fasting implies some greater benefit or inflated sense of reality that in the long run will hinder its adherents down a path that is of limited success and possibly other systemic failures including gallstone formation, which I will address later.

Therefore, I suggest that we would best be served to use the most accurate terminology, not only in this endeavor but in all things we do, because it is our own internal dialogue that ultimately matters the most.


Intermittent Fasting as most are calling it has gained much popularity as a mode of beneficial lifestyle change, but I believe that there is still much confusion out there about how to properly execute it as a program.

Once again, I want to stress the importance of calling it what it really is. Time-Restricted feeding.

One teacher, Dr. David Sinclair of Harvard University, whom I highly respect for his hard work in helping people not only overcome disease but also live longer lives practices an extreme version of this by limiting their eating to one meal per day. Most, however, limit their eating window to somewhere between 6 and 8 hours. And it is reported that this method produces favorable results. I on the other hand tend to agree with Dr. Valter Longo of the University of Southern California(USC), that the optimal feeding window is something more along the lines of 12 hours per day, and that it be held to consistently for the greatest outcome.

Though I don’t remember the exact reasoning from his fabulous book, The Longevity Diet, I do remember that he had one especially good reason for 12 hours per day being the optimal feeding window. Preventing gallstone formation.

How does gallstone formation happen?

Our bodies are very conservative and seem to be rather fond of the fruits of their labor. Bile(gall) is one of them. Bile is a yellowish-brown to a dark-green solution that is continually produced in the liver that serves to digest fats in the small intestine. And it’s as if our body refuses to waste this product, bile, that is created by storing and concentrating it in our gallbladder until the next time we partake in a meal. While being stored in the gallbladder, the bile is further concentrated by the removal of water. Hence, the formation of gallstones if it is stored for too long before being used again.

The solution is simple and should be quite obvious. Eating even a small amount of food that contains fat sends a message to the gallbladder to release bile so that it can do the work it was created for. If you are not eating for 18 hours a day or eating a diet that consists of little or no fat, you are just asking for gallstones and a strong possibility of surgical intervention to have your gallbladder removed according to Dr. Longo. A course of action that further hinders our body’s ability to attain its fullest potential of 120 healthy years.

As well, though researchers haven’t figured out exactly why studies do indicate that there is a correlation between those that forego breakfast having a much greater incidence of disease and overall mortality.

So to wrap this up, there are clear problems related to shortened feeding windows of 6 to 8 hours that can lead to gallstone formation and a possible need for surgical intervention. And on the other end of the spectrum for those eating 15 hours a day or more, other metabolic problems begin to arise along with sleeping disorders related to the practice.

My advice is similar to Dr. Valter Longo’s. Simply follow the rhythm of the equatorial sun as balance is always found in the middle. If it cannot be kissed by the sun before entering your mouth, don’t let it kiss your lips. Just remember 12 and 12.


As I promised above my thoughts on why my urinary and bowel movements have improved as I have implemented these changes.

As I mentioned in my prior two short essays, “Why Am I No Longer a Raw Vegan?” & “Fruit, Soups and Salads“, there is a proper balance of electrolytes that ultimately keep our body in a state of euhydration(sufficient hydration).

If you have ENOUGH of ALL of the electrolytes that the body requires, it will remain in a greater state of ease and homeostasis. Our bowels will move like they are supposed to and when they are supposed to because our hydration levels will be optimized. Our urinary frequency will be reduced because our kidneys will not be having to work overtime to constantly be reducing the amounts of some electrolytes to balance out ALL of them. No more insignificant visits to the bathroom and especially the ones in the middle of the night. Why? Because our body will be in a state of homeostasis where it can find rest and work on its healing and restorative processes.


Finally, Time-Restricted Feeding isn’t a quick fix as much as it is a long-term lifestyle that is part of why the Blue Zones even exist and why those in these demographics are living longer more robust lives. Not only are they eating more of the right things, but their eating patterns are inherently more aligned with what nature intended for a body with a potential to live an active 120 years.

And if you need to lose weight, don’t change the foods you eat or restrict the window by which you feed; simply eat less over the same 12-hour span.

Omega-3 Foods-[KEY]

~Content Source – allaboutvision.com

While both omega-3 and omega-6 fatty acids are important to health, the balance of these two types of EFAs in our diet is extremely important. Most experts believe the ratio of omega-6 to omega-3 fatty acids in a healthy diet should be 4-to-1 or lower.

Unfortunately, the typical American diet, characterized by significant amounts of meat and processed foods, tends to contain 10 to 30 times more omega-6 than omega-3 fatty acids. This imbalance of omega-6 (“bad”) fatty acids to omega-3 (“good”) fatty acids appears to be a contributing cause of a number of serious health problems, including heart disease, cancer, asthma, arthritis and depression.

One of the BEST STEPS YOU CAN TAKE to improve your diet is to eat more foods that are rich in omega-3 fatty acids and fewer that are high in omega-6 fatty acids.


~Content Source-healthline.com

Although your body needs both in order to function and thrive, most people take in much more omega-6 fatty acids than omega-3s.

The typical Western diet is estimated to contain as much as 20 times more omega-6s than omega-3s due to high amounts of refined vegetable oils and processed foods. Source: An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

For reference, the ratio of omega-6s to omega-3s in a traditional hunter-gatherer diet is closer to 1:1.

Further Reading

Source: The importance of a balanced ω-6 to ω-3 ratio in the prevention and management of obesity

Diets high in omega-3 fats have been linked with lower incidences of diabetes, heart disease, dementia and obesity, while diets high in omega-6 fats have been shown to increase the risk of these diseases.

Source: A fish a day, keeps the cardiologist away! – A review of the effect of omega-3 fatty acids in the cardiovascular system

Source – An Increase in the Omega-6/Omega-3 Fatty Acid Ratio Increases the Risk for Obesity

Source: Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes.

Source: The omega-6/omega-3 ratio and dementia or cognitive decline: a systematic review on human studies and biological evidence.

What If’s-2019-03-01

Happy March 2019-

What if…Bio-scenario_001-Life begins at conception and ends once decomposition ends.

What if…Cancer is a part of that biological process, a molecular bio-remediation tool used that has remote switching by the hosts immune system but no off switch. These cancers are proteins who’s DNA can be disrupted and modified.

The reason there is no off switch is because there is no need for one. These are the clean up crew that is activated upon chemical signaling caused by host death. Why would a Consumer, designed to do just that need an off switch? These cells that the cancer consume already had that function built in called apoptosis.

On occasion a host is resuscitated after the host death message is sent. The problem now being that the host is alive again but with cancer crew having already been activated.

These cancer cells once activated are set to consume the host and will continue to do so until disrupted and eradicated or until all host tissue has been consumed.

On their own each of these cells, even at post invasion levels can be overcome by the hosts immune system if it is functioning at a minimum of 90% capacity. If host immunity is below 80% full scale colonization can begin.

More to come…

…What triggers initial colonization of what will eventually become identified as a problematic cancer in the future. A tumor?

…Mary, Jesus, spot & blemish?

…3rd Trimester, Goal Posts and immune system autonomy between mother and child.

…how far back can we go with cleansing diets and digestive enzymes on full tilt?

Looking again…At the skin as an atmosphere for our body. The subcutaneous layer of our skin being equivalent to soil on Earth. Where do we make changes to our outermost layer of skin?

Process Protocol

Process Protocol(dietary/physiological) – verb: to perform a series of mechanical or chemical operations on (something) in order to change or preserve it. A transformation from a diminished usable form(someone) to a more useful and efficient pure form.

I am currently testing, on myself anyways, what I call a process protocol. This coupled with a whole-food/plant-based fare that is approximately 80/10/10. 80% whole foods. 20% fat and protein. 

The idea is to transform my alimentary tract, from nose to tail, into the equivalent of an extremely efficient sugar fermenting refinery, an efficient water treatment plant and smooth running septic system by using the same concepts found in septic systems and industrial process plants. The end result being to backpedal the effects of aging and then slow down the effects of aging as much as possible until technology can better/best us in that area too. All while effectively reducing the metabolic load on my system as a whole.

Another thing I am attempting to do is reboot, refurbish and hack my endocrine system. Get it back to what it would have looked like at say 18 years of age.

And then finally I am working on a way to improve the overall functionality of the lymphatic system to best work in my favor to rid my body of disease.

process-protocol-144My working theory, through best practices of ingestion, digestion and waste coupled with minimal exertion resistance training at maximum flexion, is that I should be able to minimize, delay or even completely hinder the effects of aging as much as humanly possible. That is make it to 100 years of age with a body that looks at most like a fit 40. And ultimately push death back to at least 144.

I imagine if I can avoid obesity and diabetes, stave off the effects of dementia for long enough, coupled with a diet that doesn’t spike insulin, that I should also be able to improve cardiovascular health and apoptosis, resulting in having a hard time not living beyond 120, barring any accidental external trauma. All with a body that halts or at least limits the process of deterioration currently associated with aging.


I was born in 1972, and I would like to see the 22nd century. My goal is 144 years of youthful living without suffering. I also imagine that, if successful, that this way of life could also solve a number of problems related to the current population status and load on our land.