Mel’s Diner

Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products.

– Melatonin has been described to possess cell protecting activity in normal cells but was shown to induce apoptotic cell death in cancer cells. It potentiates apoptosis induced by the flavonoid flavone significantly. A combination of flavone and melatonin increased caspase-3-like activity 30-fold and 80% of cells exhibited fragmentation of DNA when compared to untreated controls. Melatonin caused an increase in cytosolic lactate levels that most likely allows the flavone-induced activation of the mitochondrial pyruvate/lactate importer to deliver more substrates to mitochondrial respiration.

Melatonin Enhances the Anti-Tumor Effect of Fisetin

– Melatonin is a hormone identified in plants and pineal glands of mammals and possesses diverse physiological functions. Fisetin is a bio-flavonoid widely found in plants and exerts antitumor activity in several types of human cancers. However, the combinational effect of melatonin and fisetin on antitumor activity, especially in melanoma treatment, remains unclear. Here, we tested the hypothesis that melatonin could enhance the antitumor activity of fisetin in melanoma cells and identified the underlying molecular mechanisms. The combinational treatment of melanoma cells with fisetin and melatonin significantly enhanced the inhibitions of cell viability, cell migration and clone formation, and the induction of apoptosis when compared with the treatment of fisetin alone. Moreover, such enhancement of antitumor effect by melatonin was found to be mediated through the modulation of the multiply signaling pathways in melanoma cells.



Who Had Their Finger on the Magic of Life – Antoine Bechamp or Louis Pasteur?


Inducers of Senescence, Toxic Compounds, and Senolytics – We herein describe in vitro and in vivo effects of fifteen Nrf2-interacting natural compounds (tocotrienols, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, silybin, phenethyl isothiocyanate, sulforaphane, triptolide, allicin, berberine, piperlongumine, fisetin, and phloretin) on cellular senescence and discuss their use in adjuvant cancer therapy.

Cancer, aging and cellular senescence – Normal cells do not Continue reading linkRoll_2020.04.13

Magic Beans – Lysine and Proline

L-Proline & L-Lysine supplement
L-Proline & L-Lysine supplement label

How it Works, from

The Dr. Rath Cellular Solution is theorized to stop the spreading (i.e. metastasis) of cancer via stopping the destruction of the collagen matrix by enzymes secreted by cancerous cells, thus stopping the cancer from spreading. If the cancer is contained the body can usually deal with the cancer.

The Dr. Rath Cellular Solution

This quote explains how Dr. Rath felt cancer cells spread:

Cancer cells produce and secrete millions of enzyme molecules, which, like scissors [cancer scissors], cut collagen and tissue that surrounds cells. This picture shows how liver cancer cells use these enzymes to cut little holes in the blood vessel wall and get into the blood stream where they can travel to other organs, such as the lungs. Using the same mechanism, cancer cells can settle and start new tumor growth.

~Dr. Aleksandra Niedzwiecki, Rath Foundation

This quote explains more things about the importance of the connective tissue:

Connective tissue functions not only as a mechanical support for other tissues but also as an avenue for communication and transport among other tissues. Most significantly, connective tissue is the stage for inflammation. The principal cell types involved in immunological defense are found within connective tissue.

The Dr. Rath Cellular Solution consists of two amino acids, L-Lysine and L-Proline, plus Vitamin C, and a substance in Green Tea, the polyphenol catechin known as epigallocatechin gallate (EGCG). Laboratory trials and human trials have suggested the effectiveness of this combination.

It should be noted that Dr. Rath worked with two-time Nobel Prize winning chemist Linus Pauling on a heart disease prevention program. The three key elements of the heart prevention program are the same elements in the cancer solution (excluding the EGCG).

Additional Reading

Polyphenolic Profile and Biological Activity of Chinese Hawthorn (Crataegus pinnatifida BUNGE) Fruits


Fighting Fisetin

What an incredibly tool in the hands of a skilled craftsman. The following is my unwieldy rack of tabs. As of April 07, 2020.

Sensing seriousness about senolytics

www.fightaging.comFisetin – Animal data shows fisetin to be a surprisingly effective senolytic

Forever Healthy Knowledge Base

Fisetin Senolytic Therapy

Anticancer Efficacy of Polyphenols and Their Combinations

Blocking negative effects of senescence in human skin fibroblasts with a plant extracts