I heard this somewhere today. Cancer Without Disease. Which led me to look at this. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals.
Almost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy medicine and medicine be thy food.” Exploring the association between diet and health continues today. For example, we now know that as many as 35% of all cancers can be prevented by dietary changes. Carcinogenesis is a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor and may take up to 30 years. Continue reading Cancer Without Disease
Melatonin Enhances the Anti-Tumor Effect of Fisetin
An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer – Flavonoids, Flavonols, Quercetin, Kaempferol, Myricetin, Fisetin, Rutin, Flavanones, Hesperidin, Naringenin, Silibinin, Eriodictyol, Flavones, Acacetin, Apigenin, Chrysin, Tangeretin, Luteolin, Baicalein, Nobiletin, Flavan-3-ols (flavanols), Catechins, Proanthocyanidin, Flavanonols, Pelargonidin, Peonidin, Cyanidin, Delphinidin, Malvidin.
PDF – An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer
Medical and Dietary Uses of N-Acetylcysteine
Microbes in the Era of Circadian Medicine
Bacterial circadian rhythm | Circadian advantage
Your Body, Your System – Dr. Shiva
Escin induces caspase-dependent apoptosis and autophagy
How do anti-mitotic drugs kill cancer cells?
Anti-tubulin antibodies in autoimmune thyroid disorders.
Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cells.
Neural crest cells are a temporary group of cells unique to vertebrates that arise from the embryonic ectoderm germ layer, and in turn give rise to a diverse cell lineage—including melanocytes, craniofacial cartilage and bone, smooth muscle, peripheral and enteric neurons and glia.
The Flavonoids Hesperidin and Rutin Promote Neural Crest Cell Survival
The neural crest (NC) corresponds to a collection of multipotent and oligopotent progenitors endowed with both neural and mesenchymal potentials. The derivatives of the NC at trunk level include neurons and glial cells of the peripheral nervous system in addition to melanocytes, smooth muscle cells and some endocrine cells. Environmental factors control the fate decisions of NC cells. Despite the well-known influence of flavonoids on the central nervous system, the issue of whether they also influence NC cells has not been yet addressed. Flavonoids are polyphenolic compounds that are integral components of the human diet.
The biological activities of these compounds cover a very broad spectrum, from anticancer and antibacterial activities to inhibition of bone reabsorption and modulation of inflammatory response. In the present work, we have investigated the actions of the flavonoids hesperidin, rutin and quercetin on NC cells of quail, in vitro. We show for the first time, that hesperidin and rutin increase the viability of trunk NC cells in culture, without affecting cell differentiation and proliferation. The molecular mechanism of this action is dependent on ERK2 and PI3K pathways. Quercetin had no effect on NC progenitors. Taken together, these results suggest that flavonoids hesperidin and rutin increase NC cell survival, which may be useful against the toxicity of some chemicals during embryonic development.
Who Had Their Finger on the Magic of Life – Antoine Bechamp or Louis Pasteur?
PDF | CELLULAR SENESCENCE- AGING, CANCER, AND INJURY
Inducers of Senescence, Toxic Compounds, and Senolytics – We herein describe in vitro and in vivo effects of fifteen Nrf2-interacting natural compounds (tocotrienols, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, silybin, phenethyl isothiocyanate, sulforaphane, triptolide, allicin, berberine, piperlongumine, fisetin, and phloretin) on cellular senescence and discuss their use in adjuvant cancer therapy.
Cancer, aging and cellular senescence – Normal cells do not Continue reading linkRoll_2020.04.13