linkRoll_2020.04.20

Melatonin Enhances the Anti-Tumor Effect of Fisetin

An Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer – Flavonoids, Flavonols, Quercetin, Kaempferol, Myricetin, Fisetin, Rutin, Flavanones, Hesperidin, Naringenin, Silibinin, Eriodictyol, Flavones, Acacetin, Apigenin, Chrysin, Tangeretin, Luteolin, Baicalein, Nobiletin, Flavan-3-ols (flavanols), Catechins, Proanthocyanidin, Flavanonols, Pelargonidin, Peonidin, Cyanidin, Delphinidin, Malvidin.

PDFAn Association Map on the Effect of Flavonoids on the Signaling Pathways in Colorectal Cancer

Medical and Dietary Uses of N-Acetylcysteine

Microbes in the Era of Circadian Medicine

Bacterial circadian rhythm | Circadian advantage

Your Body, Your System – Dr. Shiva

Escin induces caspase-dependent apoptosis and autophagy

How do anti-mitotic drugs kill cancer cells?

Anti-tubulin antibodies in autoimmune thyroid disorders.

Mitotic inhibitor

Hesperidin suppressed proliferations of both human breast cancer and androgen-dependent prostate cancer cells.

The Flavonoids Hesperidin and Rutin Promote Neural Crest Cell Survival

Neural crest cells are a temporary group of cells unique to vertebrates that arise from the embryonic ectoderm germ layer, and in turn give rise to a diverse cell lineage—including melanocytes, craniofacial cartilage and bone, smooth muscle, peripheral and enteric neurons and glia.


The Flavonoids Hesperidin and Rutin Promote Neural Crest Cell Survival

The neural crest (NC) corresponds to a collection of multipotent and oligopotent progenitors endowed with both neural and mesenchymal potentials. The derivatives of the NC at trunk level include neurons and glial cells of the peripheral nervous system in addition to melanocytes, smooth muscle cells and some endocrine cells. Environmental factors control the fate decisions of NC cells. Despite the well-known influence of flavonoids on the central nervous system, the issue of whether they also influence NC cells has not been yet addressed. Flavonoids are polyphenolic compounds that are integral components of the human diet.

The biological activities of these compounds cover a very broad spectrum, from anticancer and antibacterial activities to inhibition of bone reabsorption and modulation of inflammatory response. In the present work, we have investigated the actions of the flavonoids hesperidin, rutin and quercetin on NC cells of quail, in vitro. We show for the first time, that hesperidin and rutin increase the viability of trunk NC cells in culture, without affecting cell differentiation and proliferation. The molecular mechanism of this action is dependent on ERK2 and PI3K pathways. Quercetin had no effect on NC progenitors. Taken together, these results suggest that flavonoids hesperidin and rutin increase NC cell survival, which may be useful against the toxicity of some chemicals during embryonic development.

linkRoll_2020.04.13

Who Had Their Finger on the Magic of Life – Antoine Bechamp or Louis Pasteur?

PDF | CELLULAR SENESCENCE- AGING, CANCER, AND INJURY

Inducers of Senescence, Toxic Compounds, and Senolytics – We herein describe in vitro and in vivo effects of fifteen Nrf2-interacting natural compounds (tocotrienols, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, silybin, phenethyl isothiocyanate, sulforaphane, triptolide, allicin, berberine, piperlongumine, fisetin, and phloretin) on cellular senescence and discuss their use in adjuvant cancer therapy.

Cancer, aging and cellular senescence – Normal cells do not divide indefinitely due to a process termed cellular or replicative senescence. Several lines of evidence suggest that replicative senescence evolved to protect higher eukaryotes, particularly mammals, from developing cancer. Senescent cells differ from their pre-senescent counterparts in three way:

  1. They arrest growth and cannot be stimulated to reenter the cell cycle by physiological mitogens;
  2. They become resistant to apoptotic cell death;
  3. They acquire altered differentiated functions.

Replicative senescence occurs because, owing to the biochemistry of DNA replication, cells acquire one or more critically short telomere. The mechanism by which a short telomere induces the senescent phenotype is unknown. Recent findings suggest that certain types of DNA damage and inappropriate mitogenic signals can also cause cells to adopt a senescent phenotype. Thus, cells respond to a number of potentially oncogenic stimuli by adopting a senescent phenotype. These findings suggest that the senescence response is a fail-safe mechanism that protects cells from tumorigenic transformation.

Despite the protection from cancer conveyed by cellular senescence and other mechanisms that suppress tumorigenesis, the development of cancer is almost inevitable as mammalian organisms age. Why is this the case? Certainly, aging predisposes cells to accumulate mutations, several of which are necessary before malignant transformation occurs, particularly in humans. However, many benign or relatively well-controlled tumors may also harbor many potentially oncogenic mutations, suggesting that the tissue microenvironment can suppress the expression of many malignant phenotypes. Although the idea remains controversial, cellular senescence has also been proposed to contribute to organismal aging. Senescent cells have recently been shown to accumulate with age in human tissues. One possibility is that the tissue microenvironment is disrupted by the accumulation of dysfunctional senescent cells. Thus, mutation accumulation may synergize with the accumulation of senescent cells, leading to increasing risk for developing cancer that is a hallmark of mammalian aging.

Cellular Senescence

Metabolic reprogramming and cancer progression

Anticancer Efficacy of Polyphenols and Their Combinations – Polyphenols are classified based on the number of phenol rings and the structural elements that bind these rings to one another. The groups include: phenolic acids, stilbenes, lignans, and flavonoids. Flavonoids, which have both antioxidant and anti-inflammatory properties, are found in fruits, vegetables, legumes, red wine, and green tea. They are subdivided into six classes: flavonols, flavones, isoflavones, flavanones, anthocyanidins, and flavanols (catechins and proanthocyanidins). Flavonols, the most ubiquitous flavonoids in foods, are generally present at relatively low concentrations. Quercetin and kaempferol are the main representatives, and their richest sources are onions, curly kale, leeks, broccoli, and blueberries.

Anti-androgenic effects of flavonols in prostate cancer – GOOD READ

Efflux (microbiology) – All microorganisms, with a few exceptions, have highly conserved DNA sequences in their genome that are transcribed and translated to efflux pumps. Efflux pumps are capable of moving a variety of different toxic compounds out of cells, such as antibiotics, heavy metals, organic pollutants, plant-produced compounds, quorum sensing signals, bacterial metabolites and neurotransmitters via active efflux, which is vital part for xenobiotic metabolism. Efflux pumps are proteinaceous transporters localized in the cytoplasmic membrane of all kinds of cells. They are active transporters, meaning that they require a source of chemical energy to perform their function.