How our nutrients get to where they need to go via our beautifully bountiful bacterial cafeteria workers…8) Thanks buddies
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Fighting Fisetin
What an incredibly tool in the hands of a skilled craftsman. The following is my unwieldy rack of tabs. As of April 07, 2020.
Sensing seriousness about senolytics
www.fightaging.com – Fisetin – Animal data shows fisetin to be a surprisingly effective senolytic
Forever Healthy Knowledge Base
Anticancer Efficacy of Polyphenols and Their Combinations
Blocking negative effects of senescence in human skin fibroblasts with a plant extracts
List of unproven and disproven cancer treatments
Because there had to be something behind these claims other than just whole cloth. -Wikipedia
This is a non-exhaustive list of alternative treatments that have been promoted to treat or prevent cancer in humans but which lack scientific and medical evidence of effectiveness. In many cases, there is scientific evidence that the alleged treatments are not effective. Unlike accepted cancer treatments, treatments lacking in evidence of efficacy are generally ignored or avoided by the medical community and are often pseudoscientific.
Organic Chemistry
Well…I guess the time has come for me to further educate myself in the field of organic chemistry. More to learn…Yay!!!
Alkaloids and Fibrates
Alkaloids: Alkaloids are a class of naturally occurring organic compounds that mostly contain basic nitrogen atoms. Alkaloids are produced by a large variety of organisms including bacteria, fungi, plants, and animals. Alkaloid-containing plants have been used by humans since ancient times for therapeutic and recreational purposes. Studies of alkaloids began in the 19th century. Compared with most other classes of natural compounds, alkaloids are characterized by a great structural diversity.
Fibrates: In pharmacology, the fibrates are a class of amphipathic carboxylic acids. They are used for a range of metabolic disorders, mainly hypercholesterolemia (high cholesterol), and are therefore hypolipidemic agents. Fibrates are used in accessory therapy in many forms of hypercholesterolemia, usually in combination with statins. These stimulate peroxisome proliferator activated receptor (PPAR) alpha, which controls the expression of gene products that mediate the metabolism of TG and HDL.
The Role of PPARs in Cancer– Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. PPAR𝛼 is mainly expressed in the liver, where it activates fatty acid catabolism. PPAR𝛼 activators have been used to treat dyslipidemia, causing a reduction in plasma triglyceride and elevation of high-density lipoprotein cholesterol. PPAR𝛿 is expressed ubiquitously and is implicated in fatty acid oxidation and keratinocyte differentiation. PPAR𝛿 activators have been proposed for the treatment of metabolic disease. PPAR𝛾2 is expressed exclusively in adipose tissue and plays a pivotal role in adipocyte differentiation. PPAR𝛾 is involved in glucose metabolism through the improvement of insulin sensitivity and represents a potential therapeutic target of type 2 diabetes. Thus PPARs are molecular targets for the development of drugs treating metabolic syndrome. However, PPARs also play a role in the regulation of cancer cell growth. Here, we review the function of PPARs in tumor growth.
linkRoll_2020.04.01
Can We Beat SARS-CoV-2? Lessons From Other Coronaviruses – When news broke that a novel coronavirus SARS-CoV-2 had emerged, scientists like myself were grimly aware of how difficult this novel coronavirus would be to control. For context, my research focuses on engineering bacteriophages for use as therapeutics, whereby bacterial viruses (phages) are used to infect and lyse bacteria as a replacement for traditional antibiotics. Read More…
A Huge Discovery in the World of Viruses – Giant phages have been found in French lakes, baboons from Kenya, and the human mouth. – Your mouth is currently teeming with giant viruses that, until very recently, no one knew existed. Unlike Ebola or the new coronavirus that’s currently making headlines, these particular viruses don’t cause disease in humans. They’re part of a group known as phages, which infect and kill bacteria. But while many phages are well studied, these newly discovered giants are largely mysterious. Why are they 10 times bigger than other phages? How do they reproduce? And what are they up to inside our bodies? “They’re in our saliva, and in our gut,” says Jill Banfield of the University of California, Berkeley, who led the team that discovered the new phages. “Who knows what they’re doing?” Read More…
Animal Data Shows Fisetin to be a Surprisingly Effective Senolytic – It is exciting to see animal data arrive for some of the potentially senolytic compounds that may turn out to destroy enough senescent cells in mammals to be worth using as first generation rejuvenation therapies. As a reminder, the accumulation of senescent cells is one of the causes of aging; countless cells become senescent every day in our bodies, but near all are destroyed. A tiny fraction linger to cause significant harm through the inflammatory signal molecules that they secrete. If these errant cells can be removed, then inflammatory diseases and numerous aspects of aging can be turned back to some degree. The results in mice stand head and shoulders above all of the other approaches to aging in terms of reliability and breadth of benefits…Of the 10 flavonoids tested, fisetin was the most potent senolytic. Acute or intermittent treatment of progeroid and old mice with fisetin reduced senescence markers in multiple tissues, consistent with a hit-and-run senolytic mechanism. Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan. Read More…
Flavonoids: An Overview – Flavonoids, a group of natural substances with variable phenolic structures, are found in fruits, vegetables, grains, bark, roots, stems, flowers, tea and wine. These natural products are well known for their beneficial effects on health and efforts are being made to isolate the ingredients so called flavonoids. Flavonoids are now considered as an indispensable component in a variety of nutraceutical, pharmaceutical, medicinal and cosmetic applications. This is attributed to their anti-oxidative, anti-inflammatory, anti-mutagenic and anti-carcinogenic properties coupled with their capacity to modulate key cellular enzyme function. Read More…
Chemistry and Biological Activities of Flavonoids: An Overview – Flavonoids consist of a large group of polyphenolic compounds having a benzo-γ-pyrone structure and are ubiquitously present in plants. Flavonoids are hydroxylated phenolic substances and are known to be synthesized by plants in response to microbial infection. Many flavonoids are shown to have antioxidative activity, free radical scavenging capacity, coronary heart disease prevention, hepatoprotective, anti-inflammatory, and anticancer activities, while some flavonoids exhibit potential antiviral activities. In plant systems, flavonoids help in combating oxidative stress and act as growth regulators. Read More…
Fisetin is a senotherapeutic that extends health and lifespan – The natural product fisetin has senotherapeutic activity in mice and in human tissues. Late life intervention was sufficient to yield a potent health benefit. These characteristics suggest the feasibility to translation to human clinical studies.
Lectures on auto-intoxication in disease, or, Self-poisoning of the individual
linkRoll_2020.03.29
The Kynurenine Superhighway
Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications
What is the tryptophan kynurenine pathway and why is it important to neurotherapy?
The Kynurenine Pathway As a Novel Link between Allergy and the Gut Microbiome
Prior Days linkRoll_2020.03.29 – Tab Clearance…LoL
Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection
Schizophrenia: An Update of the Selenium Deficiency Hypothesis
Selenium Deficiency and Clinical Findings in Schizophrenia
Association of Elements with Schizophrenia and Intervention of Selenium Supplements
Low blood selenium concentrations in schizophrenic patients on clozapine
Niacin in the Central Nervous System: An Update of Biological Aspects and Clinical Applications
Niacin use and cutaneous flushing: mechanisms and strategies for prevention
Nicotinic Acid Activates the Capsaicin Receptor TRPV1 – Potential Mechanism for Cutaneous Flushing
Seeing red: flushing out instigators of niacin-associated skin toxicity
Heating Up the Cutaneous Flushing Response
Mechanisms of Flushing Due to Niacin and Abolition of These Effects
The mechanism and mitigation of niacin-induced flushing
Schizophrenia Is Really Schizophrenias
We should not overlook the fact that schizophrenia is really schizophrenias (plural). For example pellagra, still around in many parts of the world, may be [mislabeled as schizophrenia]. Similarly, cerebral allergic reactions to gluten (gluteomorphin) can give rise to clinical features that would be [indistinguishable from schizophrenia], and therefore would be [overlooked by most psychiatrists].
Hoffer himself sometimes moved away from the adrenochrome hypothesis. For example, he advised us to think of alternate treatments (i.e., hypotheses) if a patient had not responded to therapeutic doses of niacin. Hoffer considered hypothyroidism as a possible cause of schizophrenia. He even quoted a study by Danziger that showed recoveries in 80 schizophrenic patients that were administered natural desiccated thyroid for at least 100 days, and who were ill for six months or less.
Foster, Pataracchia, Campbell McBride, and others have summarized the alternate causes or hypotheses of schizophrenia, such as subclinical hypothyroidism, cerebral allergy to gluten, sugar and petro chemical inhalants[HUFFING/VAPING?], heavy metal toxicity, and candida/gut dysbiosis. In any individual case, any combination of causes might be implicated in the genesis of the schizophrenia syndrome.
Although, at least to my knowledge, adrenochrome has not been measured and compared between schizophrenic, nonschizophrenic and normal control groups of population, we can draw conclusions in favor of niacin and hence, indirectly for the adrenochrome hypothesis, from Hoffer’s studies and reports that spanned many decades. Outside of Hoffer, there have been publications giving indirect credence to the adrenochrome hypothesis. For example, Wittenborn published data demonstrating that acute-onset patients (ill for six months or less) were having intact inter-personal relations as a result of niacin treatment.
Hoffer’s writings also stressed the value of psychosocial factors when he talked of food, shelter, and respect as critically valuable factors in recovery without psychiatric drugs. In the case of chronic schizophrenic patients, who are likely to develop negative symptoms, much like the well known symptoms of “institutionalization or hospitalization syndrome,” the useful hypothesis may be something other than the adrenochrome hypothesis. There is even evidence of gluten sensitivity in chronic schizophrenic patients. They may have become chronic because the treating physician didn’t consider gluten as a hypothesis of schizophrenia. A 2009 publication described a lifelong schizophrenic patient that recovered following a gluten-free, low-carbohydrate ketogenic diet.
Schizophrenia, Cancer and the Hoff
Schizophrenia and cancer: the adrenochrome balanced morphism.
Abstract
Cancer might be expected to be more common amongst schizophrenics than the general population. They frequently live in selenium deficient regions, have seriously compromised antioxidant defense systems and chain-smoke. The available literature on the cancer-schizoprenia relationship in patients from England, Wales, Ireland, Denmark, USA and Japan, however, strongly suggests that the reverse is true. One of the authors (Hoffer) has treated 4000 schizophrenics since 1952. Only four of these patients has developed cancer.
Since low cancer incidence has been recorded amongst patients treated by both conventional physicians using pharmaceuticals and by orthomolecular doctors who emphasize vitamins and minerals, it follows that this depressed cancer incidence must be related to the biochemistry of the disorder itself. Taken as a whole, therefore, the evidence seems to suggest that schizophrenics, their siblings and parents are less susceptible to cancer than the general population.
These relationships seem compatible with one or more genetic risk factors for schizophrenia that offer(s) a selective advantage against cancer. There is experimental evidence that appears to support this possibility. Matrix Pharmaceuticals Inc. has received a US patent covering the composition of IntraDose Injectable Gel. This gel contains cisplatin and epinephrine (adrenaline) and is designed to be injected directly into tumor masses. Cisplatin is a very powerful oxidant which will almost certainly rapidly convert the adrenaline to adrenochrome. While the manufacturers of IntraDose consider cisplatin to be the active cytotoxic agent in IntraDose, it seems more likely that adrenochrome and its derivatives may, in fact, be more effective.
IntraDose gel has undergone or is undergoing a series of Phase III open-label clinical studies, being injected into patients’ tumors that have been identified as the most troublesome by their physicians. The results have been impressive for breast cancer, malignant melanoma, esophageal cancer and cancer of the head, neck and liver. The evidence suggests that there are balanced morphisms in schizophrenia that result in above normal exposure to catecholamine derivatives. Since such catecholamines are both hallucinogenic and anti-carcinogenic abnormally high exposure to them simultaneously increases susceptibility to schizophrenia and reduces the probability of developing cancer.
These observations have significant implications for the treatment of both illnesses.