Inducers of Senescence, Toxic Compounds, and Senolytics – We herein describe in vitro and in vivo effects of fifteen Nrf2-interacting natural compounds (tocotrienols, curcumin, epigallocatechin gallate, quercetin, genistein, resveratrol, silybin, phenethyl isothiocyanate, sulforaphane, triptolide, allicin, berberine, piperlongumine, fisetin, and phloretin) on cellular senescence and discuss their use in adjuvant cancer therapy.
Normal cells do not divide indefinitely due to a process termed cellular or replicative senescence. Several lines of evidence suggest that replicative senescence evolved to protect higher eukaryotes, particularly mammals, from developing cancer. Senescent cells differ from Continue reading Cancer, aging and cellular senescence.
WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Despite the treatable dementia and psychosis, pellagra is often under-diagnosed, especially in developed countries and alcoholic patients. Pellagra should be routinely suspected in alcoholic patients because the response to appropriate treatment is typically dramatic.
Alcoholic Pellagra as a Cause of Altered Mental Status in the Emergency Department ~ Source-NIH
BACKGROUND:
Pellagra, which is caused by a deficiency of niacin and tryptophan, the precursor of niacin, is a rare disease in developed countries where alcoholism is a major risk factor due to malnutrition and lack of B vitamins. Although pellagra involves treatable dementia and psychosis, it is often underdiagnosed, especially in developed countries.
CASE REPORT:
In Japan, a 37-year-old man presented to the emergency department with altered mental status and seizures. Wernicke encephalopathy and alcohol withdrawal were suspected. The patient was treated with multivitamins, which did not include nicotinic acid amide, and oral diazepam. Despite medical treatment, his cognitive impairment progressively worsened, and eventually, pellagra was suspected. His response to treatment with nicotinic acid amide was substantial, and he was discharged without any long-term sequelae. WHY SHOULD AN EMERGENCY PHYSICIAN BE AWARE OF THIS?: Despite the treatable dementia and psychosis, pellagra is often underdiagnosed, especially in developed countries and alcoholic patients. Pellagra should be routinely suspected in alcoholic patients because the response to appropriate treatment is typically dramatic.
Respecting the pectin. Such a wonderfully powerful health resource.
Abstract
A simple procedure for determining the galacturonic acid and methanol contents of soluble and insoluble pectins, relying on enzymatic pectin hydrolysis and colorimetric quantification, is described. Pectin samples are incubated with a commercial pectinase preparation, Viscozyme, then the galacturonic acid content of the hydrolyzed pectin is quantified colorimetrically using a modification of the Cu reduction procedure originally described by Avigad and Milner. This modification, substituting the commonly used Folin-Ciocalteau reagent for the arsenic containing Nelson reagent, gives a response that is linear, sensitive, and selective for uronic acids over neutral sugars. This method also avoids the use of concentrated acids needed for the commonly used m-phenylphenol method. Methanol, released by the action of the pectin methylesterase found in the Viscozyme, is quantified using alcohol oxidase and Purpald. This combined enzymatic and colorimetric procedure correctly determined the galacturonic acid and methanol content of purified, soluble citrus pectin. Application of the procedure to water insoluble pectins was evaluated with water insoluble material from apples and oranges. In both cases good agreement was obtained between this method and commonly used methods based on chemical pectin hydrolysis. Good agreement between these procedures was also found in the analysis of both soluble and insoluble pectins from several tomato products.
Layman’s explanation: Galacturonic acid is the monobasic acid resulting from oxidation of the primary alcohol group of D-galactose to carboxyl. It is widely distributed as a constituent of pectins (compounds with heterogeneous grouping of acidic structural polysaccharides, found in fruit and vegetables), many plant gums, and mucilages (gummy substances obtained from certain plants, which are used as food stabilizers). Gums tend to be used as thickening and bulking agents in pharmaceutics, and they play a less obvious part in most plants. Once swallowed, their actions are no different from those of the mucilages. D-Galacturonic acid prepared from pectin can be used to synthesize vitamin C. Native pectin is a mixture of polysaccharides, with the major component a polymer of -D-galacturonic acid. Pectin has numerous other medical and pharmaceutical uses, for example in combination with plant hemicelluloses and lignin, may be useful dietary constituents in preventing coronary heart disease, diverticular disease, ulcerative colitis, and a variety of other Western diseases.
The Dr. Rath Cellular Solution is theorized to stop the spreading (i.e. metastasis) of cancer via stopping the destruction of the collagen matrix by enzymes secreted by cancerous cells, thus stopping the cancer from spreading. If the cancer is contained the body can usually deal with the cancer.
The Dr. Rath Cellular Solution
This quote explains how Dr. Rath felt cancer cells spread:
Cancer cells produce and secrete millions of enzyme molecules, which, like scissors [cancer scissors], cut collagen and tissue that surrounds cells. This picture shows how liver cancer cells use these enzymes to cut little holes in the blood vessel wall and get into the blood stream where they can travel to other organs, such as the lungs. Using the same mechanism, cancer cells can settle and start new tumor growth.
~Dr. Aleksandra Niedzwiecki, Rath Foundation
This quote explains more things about the importance of the connective tissue:
Connective tissue functions not only as a mechanical support for other tissues but also as an avenue for communication and transport among other tissues. Most significantly, connective tissue is the stage for inflammation. The principal cell types involved in immunological defense are found within connective tissue.
The Dr. Rath Cellular Solution consists of two amino acids, L-Lysine and L-Proline, plus Vitamin C, and a substance in Green Tea, the polyphenol catechin known as epigallocatechin gallate (EGCG). Laboratory trials and human trials have suggested the effectiveness of this combination.
It should be noted that Dr. Rath worked with two-time Nobel Prize winning chemist Linus Pauling on a heart disease prevention program. The three key elements of the heart prevention program are the same elements in the cancer solution (excluding the EGCG).
Because there had to be something behind these claims other than just whole cloth. -Wikipedia
This is a non-exhaustive list of alternative treatments that have been promoted to treat or prevent cancer in humans but which lack scientific and medical evidence of effectiveness. In many cases, there is scientific evidence that the alleged treatments are not effective. Unlike accepted cancer treatments, treatments lacking in evidence of efficacy are generally ignored or avoided by the medical community and are often pseudoscientific.
